Interleukin-10 production at the early stage of infection with foot-and-mouth disease virus related to the likelihood of persistent infection in cattle

被引：14
作者：
Zhang, Zhidong [1 ,2 ]
Doel, Claudia [2 ,3 ]
Bashiruddin, John B. [2 ,4 ]
机构：
[1] Lanzhou Vet Res Inst, State Key Lab Vet Etiol Biol, Lanzhou 730046, Gansu, Peoples R China
[2] Pirbright Inst, Woking GU24 0NF, Surrey, England
[3] DCD Consulting Ltd, Alton GU34 5BG, Hants, England
[4] JBBiol, Farnham GU10 1DH, Surrey, England
来源：
VETERINARY RESEARCH | 2015年 / 46卷
基金：
英国生物技术与生命科学研究理事会;
关键词：
CARRIER STATE; HEPATITIS-C; REPLICATION; INTERFERON; IL-10; CELLS; SWINE; ELISA;
D O I：
10.1186/s13567-015-0276-y
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
The factors leading to persistent infection of foot-and-mouth disease (FMD) virus in ruminants are not well defined. This paper provides evidence of the presence of interleukin-10 (IL-10) early in the course of infection (1-4 days) as a factor in the development of persistence of FMD virus in cattle. Results showed that serum IL-10 in carrier cattle infected with FMD virus type O (n = 4) was detected and peaked at 1 or 2 days post infection and rapidly declined thereafter. In contract, serum IL-10 levels in non-carrier cattle (n = 21) were very low or undetectable during the same period.
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页数：5
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