Adeno-associated Vector Toxicity-To Be or Not to Be?

被引：60
作者：
Buening, Hildegard [1 ]
Schmidt, Manfred [2 ,3 ]
机构：
[1] Hannover Med Sch, Inst Expt Hematol, Hannover, Germany
[2] Natl Ctr Tumor Dis NCT, Heidelberg, Germany
[3] German Canc Res Ctr, Dept Translat Oncol, Heidelberg, Germany
来源：
MOLECULAR THERAPY | 2015年 / 23卷 / 11期
关键词：
GENE-THERAPY; INTEGRATION SITES; VIRUS; LIVER; MICE; GENOTOXICITY; TISSUES;
D O I：
10.1038/mt.2015.182
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
引用
收藏
页码：1673 / 1675
页数：3
相关论文
共 24 条
  • [1] The AAV Vector Toolkit: Poised at the Clinical Crossroads
    Asokan, Aravind
    Schaffer, David V.
    Samulski, R. Jude
    [J]. MOLECULAR THERAPY, 2012, 20 (04) : 699 - 708
  • [2] Adeno-associated virus may play a protective role against human papillomavirus-induced cervical lesions independent of HIV serostatus
    Bueno de Freitas, L.
    Tonani de Mattos, A.
    Lima, B. M. C.
    Miranda, A. E.
    Spano, L. C.
    [J]. INTERNATIONAL JOURNAL OF STD & AIDS, 2012, 23 (04) : 258 - 261
  • [3] Vector design influences hepatic genotoxicity after adeno-associated virus gene therapy
    Chandler, Randy J.
    LaFave, Matthew C.
    Varshney, Gaurav K.
    Trivedi, Niraj S.
    Carrillo-Carrasco, Nuria
    Senac, Julien S.
    Wu, Weiwei
    Hoffmann, Victoria
    Elkahloun, Abdel G.
    Burgess, Shawn M.
    Venditti, Charles P.
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2015, 125 (02) : 870 - 880
  • [4] AAV vector integration sites in mouse hepatocellular carcinoma
    Donsante, Anthony
    Miller, Daniel G.
    Li, Yi
    Vogler, Carole
    Brunt, Elizabeth M.
    Russell, David W.
    Sands, Mark S.
    [J]. SCIENCE, 2007, 317 (5837) : 477 - 477
  • [5] Clades of Adeno-associated viruses are widely disseminated in human tissues
    Gao, GP
    Vandenberghe, LH
    Alvira, MR
    Lu, Y
    Calcedo, R
    Zhou, XY
    Wilson, JA
    [J]. JOURNAL OF VIROLOGY, 2004, 78 (12) : 6381 - 6388
  • [6] Gil-Farina I, 2015, ANN M EUR SOC GEN CE
  • [7] Adeno-Associated Virus at 50: A Golden Anniversary of Discovery, Research, and Gene Therapy Success-A Personal Perspective
    Hastie, Eric
    Samulski, R. Jude
    [J]. HUMAN GENE THERAPY, 2015, 26 (05) : 257 - 265
  • [8] Integration Preferences of Wildtype AAV-2 for Consensus Rep-Binding Sites at Numerous Loci in the Human Genome
    Hueser, Daniela
    Gogol-Doering, Andreas
    Lutter, Timo
    Weger, Stefan
    Winter, Kerstin
    Hammer, Eva-Maria
    Cathomen, Toni
    Reinert, Knut
    Heilbronn, Regine
    [J]. PLOS PATHOGENS, 2010, 6 (07) : 1 - 14
  • [9] The role of DNA-PKcs and artemis in opening viral DNA hairpin termini in various tissues in mice
    Inagaki, Katsuya
    Ma, Congrong
    Storm, Theresa A.
    Kay, Mark A.
    Nakai, Hiroyuki
    [J]. JOURNAL OF VIROLOGY, 2007, 81 (20) : 11304 - 11321
  • [10] A largely random AAV integration profile after LPLD gene therapy
    Kaeppel, Christine
    Beattie, Stuart G.
    Fronza, Raffaele
    van Logtenstein, Richard
    Salmon, Florence
    Schmidt, Sabine
    Wolf, Stephan
    Nowrouzi, Ali
    Glimm, Hanno
    von Kalle, Christof
    Petry, Harald
    Gaudet, Daniel
    Schmidt, Manfred
    [J]. NATURE MEDICINE, 2013, 19 (07) : 889 - +
123