Arsenic exposure and respiratory outcomes during childhood in the INMA study

被引:5
作者
Signes-Pastor, Antonio J. [1 ,2 ,3 ]
Diaz-Coto, Susana [4 ]
Martinez-Camblor, Pablo [5 ]
Carey, Manus [6 ]
Soler-Blasco, Raquel [7 ]
Garcia-Villarino, Miguel [2 ,8 ,9 ]
Fernandez-Somoano, Ana [2 ,8 ,9 ]
Julvez, Jordi [2 ,10 ,11 ]
Carrasco, Paula [7 ,12 ]
Lertxundi, Aitana [2 ,13 ,14 ]
Santa Marina, Loreto [2 ,14 ,15 ]
Casas, Maribel [11 ,16 ]
Meharg, Andrew A. [6 ]
Karagas, Margaret R. [5 ]
Vioque-Lopez, Jesus [1 ,2 ,3 ]
机构
[1] Univ Miguel Hernandez, Unidad Epidemiol Nutr, Alicante, Spain
[2] Inst Salud Carlos III ISCIII, CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain
[3] Inst Invest Sanitaria & Biomed Alicante ISABIAL, Alicante, Spain
[4] Dartmouth Coll, Geisel Sch Med, Dept Epidemiol, 1 Med Ctr Dr, Lebanon, NH 03756 USA
[5] Dartmouth Coll, Geisel Sch Med, Biomed Data Sci Dept, Lebanon, NH 03756 USA
[6] Queens Univ Belfast, Inst Global Food Secur, Sch Biol Sci Bldg, Belfast, Antrim, North Ireland
[7] FISABIO Univ Jaume I Univ Valencia, Epidemiol & Environm Hlth Joint Res Unit, Valencia, Spain
[8] Univ Oviedo, Univ Inst Oncol Principal Asturias IUOPA, Unit Mol Canc Epidemiol, Dept Med, Oviedo, Asturias, Spain
[9] Inst Hlth Res Principal Asturias ISPA, Oviedo, Spain
[10] Hosp Univ St Joan Reus, Inst Invest Sanitaria Pere Virgili, Reus, Spain
[11] ISGlobal Inst Salud Global Barcelona Campus MAR, Parc Recerca Biorned Barcelona PRBB, Barcelona, Spain
[12] Univ Jaume 1, Dept Med, Castellon De La Plana, Spain
[13] Univ Basque Country, Dept Prevent Med & Publ Hlth, Leioa, Basque Country, Spain
[14] Hlth Res Inst, Biodonostia, Donostia San Se, Spain
[15] Dept Hlth Basque Govt, Publ Hlth Div Gipuzkoa, Donostia San Sebastian, Spain
[16] Univ Pompeu Fabra, Barcelona, Spain
来源
PLOS ONE | 2022年 / 17卷 / 09期
关键词
EARLY-LIFE EXPOSURE; LUNG-FUNCTION; DRINKING-WATER; URINARY-EXCRETION; CYTOKINE SECRETION; OXIDATIVE STRESS; SEAFOOD INTAKE; CHILDREN; UTERO; SYMPTOMS;
D O I
10.1371/journal.pone.0274215
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Ingested inorganic arsenic (iAs) is a human carcinogen that is also linked to other adverse health effects, such as respiratory outcomes. Yet, among populations consuming low-arsenic drinking water, the impact of iAs exposure on childhood respiratory health is still uncertain. For a Spanish child study cohort (INfancia y Medio Ambiente-INMA), low-arsenic drinking water is usually available and ingestion of iAs from food is considered the major source of exposure. Here, we explored the association between iAs exposure and children's respiratory outcomes assessed at 4 and 7 years of age (n = 400). The summation of 4-year-old children's urinary iAs, monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA) was used as a biomarker of iAs exposure (Sigma As) (median of 4.92 mu g/L). Children's occurrence of asthma, eczema, sneeze, wheeze, and medication for asthma and wheeze at each assessment time point (i.e., 4- and 7-year) was assessed with maternal interviewer-led questionnaires. Crude and adjusted Poisson regression models using Generalized Estimating Equation (GEE) were performed to account for the association between natural logarithm transformed (In) urinary Sigma As in mu g/L at 4 years and repeated assessments of respiratory symptoms at 4 and 7 years of age. The covariates included in the models were child sex, maternal smoking status, maternal level of education, sub-cohort, and children's consumption of vegetables, fruits, and fish/seafood. The GEE-splines function using Poisson regression showed an increased trend of the overall expected counts of respiratory symptoms with high urinary Sigma As. The adjusted expected counts (95% confidence intervals) at In-transformed urinary Sigma As 1.57 (average concentration) and 4.00 (99th percentile concentration) were 0.63 (0.36, 1.10) and 1.33 (0.61, 2.89), respectively. These exploratory findings suggest that even relatively low-iAs exposure levels, relevant to the Spanish and other populations, may relate to an increased number of respiratory symptoms during childhood.
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页数:14
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