Immunomodulation of human macrophages and myeloid cells by 2-substituted (1-3)-β-D-glucan from P. parvulus 2.6

被引:24
|
作者
Notararigo, Sara [1 ]
de las Casas-Engel, Mateo [1 ]
Fernandez de Palencia, Pilar [1 ]
Corbi, Angel L. [1 ]
Lopez, Paloma [1 ]
机构
[1] CSIC, Ctr Invest Biol, Dept Mol Microbiol & Infect Biol, E-28040 Madrid, Spain
关键词
2-Substituted (1-3)-beta-D-glucan; Exopolysaccharides; Macrophages modulation; Lactic acid bacteria; INFLAMMATORY-BOWEL-DISEASE; NECROSIS-FACTOR-ALPHA; DENDRITIC CELL; POLYSACCHARIDES; EXPRESSION; BACTERIA;
D O I
10.1016/j.carbpol.2014.05.073
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
beta-glucans produced by eukaryotic cells and by microorganisms are known to modulate immune responses by affecting macrophage activation. Here, we have investigated the effect of purified 2-substituted (1-3)-beta-D-glucan, produced by either Pediococcus parvulus 2.6 or Lactococcus lactis NZ9000[pNGTF], on the effector functions of human PMA-differentiated THP-1 cells and M1 pro-inflammatory monocyte-derived macrophages. The results reveal that this kind of beta-D-glucan activates macrophages and has an anti-inflammatory effect. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码:109 / 113
页数:5
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