CASP8 D302H and meningioma risk: An analysis of five case-control series

被引：18

作者：

Bethke, Lara ^{[1
]}

Sullivan, Kate ^{[1
]}

Webb, Emily ^{[1
]}

Murray, Anne ^{[1
]}

Schoemaker, Minouk ^{[2
]}

Auvinen, Anssi ^{[3
,4
]}

Kiuru, Anne ^{[3
]}

Salminen, Tiina ^{[3
,4
]}

Johansen, Christoffer ^{[5
]}

Christensen, Helle Collatz ^{[5
]}

Muir, Kenneth ^{[6
]}

McKinney, Patricia ^{[7
]}

Hepworth, Sarah ^{[7
]}

Dimitropoulou, Polyxeni ^{[6
]}

Lophatananon, Artitaya ^{[6
]}

Feychting, Maria ^{[8
]}

Lonn, Stefan ^{[9
]}

Ahlbom, Anders ^{[8
]}

Malmer, Beatrice ^{[10
]}

Henriksson, Roger ^{[10
]}

Swerdlow, Anthony ^{[2
]}

Houlston, Richard ^{[1
]}

机构：

[1] Inst Canc Res, Sect Canc Genet, Sutton SM2 5NG, Surrey, England

[2] Inst Canc Res, Epidemiol Sect, Sutton SM2 5NG, Surrey, England

[3] Univ Tampere, Tampere Sch Publ Hlth, Dept Epidemiol, FIN-33016 Tampere, Finland

[4] STUK, Radiat & Nucl Safety Author, Dept Res & Environm Surveillance, FIN-00881 Helsinki, Finland

[5] Danish Canc Soc, Inst Canc Epidemiol, DK-2100 Copenhagen, Denmark

[6] Univ Nottingham, Sch Med, Queens Med Ctr, Div Epidemiol & Publ Hlth, Nottingham NG7 2UH, England

[7] Ctr Biostat & Epidemiol, Leeds LS2 9LN, W Yorkshire, England

[8] Karolinska Inst, Inst Environm Med, Div Epidemiol, S-17177 Stockholm, Sweden

[9] Karolinska Inst, Dept Med Epidemiol & Biostat, S-17177 Stockholm, Sweden

[10] Umea Univ, Dept Radiat Sci, S-90185 Umea, Sweden

来源：

CANCER LETTERS | 2009年 / 273卷 / 02期

基金：

瑞典研究理事会;

关键词：

Caspase; 8; Polymorphism; Meningioma; Risk; PROMOTER POLYMORPHISM; CANCER; VARIANT; TUMORS;

D O I：

10.1016/j.canlet.2008.08.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Caspase 8 (CASP8) is a key regulator of apoptosis or programmed cell death, and hence a defence against cancer. The CASP8 polymorphism D302H has recently been shown to influence the risk of breast cancer. We tested the hypothesis that the CASP8 polymorphism D302H may influence risk of meningioma through analysis of five independent series of case patients and controls (n = 631 and 637, respectively). Carrier status for 302H was not associated with a statistically significantly increased risk (OR= 1.16; 95% CI: 0.87-1.53; P=0.31) making it unlikely that this variant contributes to the inherited risk of meningioma. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：312 / 315

页数：4

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