Multidrug Resistance in Bacteria

被引：1098

作者：

Nikaido, Hiroshi ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

来源：

ANNUAL REVIEW OF BIOCHEMISTRY | 2009年 / 78卷

基金：

美国国家卫生研究院;

关键词：

R plasmids; transposons; integrons; type IV secretion system; multidrug efflux pumps; MEMBRANE-FUSION PROTEIN; EFFLUX PUMP ACRB; ESCHERICHIA-COLI; PSEUDOMONAS-AERUGINOSA; CRYSTAL-STRUCTURE; STAPHYLOCOCCUS-AUREUS; SUBSTRATE-SPECIFICITY; ABC TRANSPORTER; SYSTEM; MECHANISMS;

D O I：

10.1146/annurev.biochem.78.082907.145923

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Large amounts of antibiotics used for human therapy, as well as for farm animals and even for fish in aquaculture, resulted in the selection of pathogenic bacteria resistant to multiple drugs. Multidrug resistance in bacteria may be generated by one of two mechanisms. First, these bacteria may accumulate multiple genes, each coding for resistance to a single drug, Within a single cell. This accumulation occurs typically on resistance (R) plasmids. Second, multidrug resistance may also occur by the increased expression of genes that code for multidrug efflux pumps, extruding a wide range of drugs. This review discusses our current knowledge on the molecular mechanisms involved in both types of resistance.

引用

页码：119 / 146

页数：28

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