Spatio-temporal optical coherence tomography provides full thickness imaging of the chorioretinal complex

被引:15
作者
Auksorius, Egidijus [1 ,2 ,3 ]
Borycki, Dawid [1 ,3 ]
Wegrzyn, Piotr [1 ,3 ,4 ]
Sikorski, Bartosz L. [5 ,6 ]
Lizewski, Kamil [1 ,3 ]
Zickiene, Ieva [2 ]
Rapolu, Mounika [1 ,3 ]
Adomavicius, Karolis [2 ]
Tomczewski, Slawomir [1 ,3 ]
Wojtkowski, Maciej [1 ,3 ]
机构
[1] Int Ctr Translat Eye Res ICTER, ul Skierniewicka 10a, PL-01230 Warsaw, Poland
[2] Ctr Phys Sci & Technol FTMC, Sauletekio al 3, VT-10257 Vilnius, Lithuania
[3] Inst Phys Chem, Polish Acad Sci, Kasprzaka 44-52, PL-01224 Warsaw, Poland
[4] Univ Warsaw, Fac Phys, Pasteura 5, PL-02093 Warsaw, Poland
[5] Nicolaus Copernicus Univ, Dept Ophthalmol, Sklodowskiej Curie 9, PL-85090 Bydgoszcz, Poland
[6] Eye Res & Dev Ctr, Oculomed, Ogrody 14, PL-85870 Bydgoszcz, Poland
关键词
ADAPTIVE OPTICS; MACULAR DEGENERATION; CHOROIDAL VASCULATURE; ABERRATION CORRECTION; HUMAN RETINA; FIELD OCT; CHORIOCAPILLARIS; RESOLUTION; ANGIOGRAPHY; REGISTRATION;
D O I
10.1016/j.isci.2022.105513
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Despite the rapid development of optical imaging methods, high-resolution in vivo imaging with penetration into deeper tissue layers is still a major challenge. Optical coherence tomography (OCT) has been used successfully for non-invasive human retinal volumetric imaging in vivo, advancing the detection, diagnosis, and monitoring of various retinal diseases. However, there are important limitations of volumetric OCT imaging, especially coherent noise and the limited axial range over which high resolution images can be acquired. The limited range prevents simultaneous measurement of the retina and choroid with adequate lateral resolution. In this article, we address these limitations with a technique that we term spatio-temporal optical coherence tomography (STOC-T), which uses light with controlled spatial and temporal coherence and advanced signal processing methods. STOC-T enabled the acquisition of high-contrast and high-resolution coronal projection images of the retina and choroid at arbitrary depths.
引用
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页数:22
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