A Systems Medicine Clinical Platform for Understanding and Managing Non-Communicable Diseases

被引：29

作者：

Cesario, Alfredo ^{[1
]}

Auffray, Charles ^{[2
]}

Agusti, Alvar ^{[3
,4
]}

Apolone, Giovanni ^{[5
]}

Balling, Rudi ^{[6
]}

Barbanti, Piero ^{[7
]}

Bellia, Alfonso ^{[8
]}

Boccia, Stefania ^{[9
,10
]}

Bousquet, Jean ^{[11
,12
]}

Cardaci, Vittorio ^{[13
]}

Cazzola, Mario ^{[8
]}

Dall'Armi, Valentina ^{[10
]}

Daraselia, Nikolai ^{[14
]}

Da Ros, Lucio

Del Bufalo, Alessandra ^{[15
]}

Ducci, Giuseppe ^{[16
]}

Ferri, Luigi ^{[17
]}

Fini, Massimo ^{[18
]}

Fossati, Chiara ^{[19
]}

Gensini, Gianfranco ^{[20
]}

Granone, Pierluigi Maria ^{[21
]}

Kinross, James ^{[22
]}

Lauro, Davide ^{[8
]}

Lo Cascio, Gerland ^{[23
]}

Lococo, Filippo ^{[24
]}

Lococo, Achille ^{[25
]}

Maier, Dieter ^{[26
]}

Marcus, Frederick

Margaritora, Stefano ^{[20
,27
]}

Marra, Camillo ^{[28
]}

Minati, Gianfranco ^{[29
]}

Neri, Monica ^{[10
]}

Pasqua, Franco ^{[30
,31
]}

Pison, Christophe ^{[32
,33
]}

Pristipino, Christian ^{[34
]}

Roca, Joseph ^{[35
]}

Rosano, Giuseppe ^{[36
]}

Rossini, Paolo Maria ^{[37
,38
,39
]}

Russo, Patrizia ^{[15
]}

Salinaro, Gianluca ^{[15
]}

Shenhar, Shani ^{[40
]}

Soreq, Hermona ^{[40
]}

Sterk, Peter J. ^{[41
]}

Stocchi, Fabrizio ^{[19
]}

Torti, Margherita ^{[19
]}

Volterrani, Maurizio ^{[42
]}

Wouters, Emiel F. M. ^{[43
]}

Frustaci, Alessandra

Bonassi, Stefano ^{[10
]}

机构：

[1] IRCCS San Raffaele Pisana, Deputy Sci Director & Syst Med Coordinator, I-00166 Rome, Italy

[2] Univ Lyon, CNRS ENS UCBL, European Inst Syst Biol & Med, Lyon, France

[3] Univ Barcelona, IDIBAPS, Thorax Inst, Hosp Clin, Mallorca, Spain

[4] CIBER Enfermedades Resp CIBERES, FISIB, Mallorca, Spain

[5] Irccs Arcispedale S Maria Nuova, Sci Directorate, Reggio Emilia, Italy

[6] Univ Luxembourg, LCSB, Luxembourg, Luxembourg

[7] IRCCS San Raffaele Pisana, Dept Neurol Motor & Sensorial Sci, Headache & Pain Unit, Rome, Italy

[8] Univ Roma Tor Vergata, Dept Syst Med, I-00173 Rome, Italy

[9] Univ Cattolica Sacro Cuore, Fac Med, Dept Publ Hlth, Inst Publ Hlth,Sect Hyg, Rome, Italy

[10] IRCCS San Raffaele Pisana, Unit Clin & Mol Epidemiol, Area Syst Approaches & Non Communicable Dis, Rome, Italy

[11] INSERM, CESP Ctr Res Epidemiol & Populat Hlth, Resp & Environm Epidemiol Team, F-94807 Villejuif, France

[12] Univ Paris 11, UMRS 1018, F-94807 Villejuif, France

[13] IRCCS San Raffaele Pisana, Dept Pulm Rehabil, Rome, Italy

[14] Elsevier Inc, Rockville, MD USA

[15] IRCCS San Raffaele Pisana, Lab Syst Approaches & Non Communicable Dis, Rome, Italy

[16] Mental Hlth Dept Rome E, Rome, Italy

[17] San Raffaele Cassino, Dept Pulm Rehabil, Cassino, FR, Italy

[18] IRCCS San Raffaele Pisana, Sci Director, Rome, Italy

[19] IRCCS, Ctr Parkinsons Dis & Other Movement Disorders, Rome, Italy

[20] Univ Florence, Dept Expt & Clin Med, AOU Careggi, Fdn Don Carlo Gnocchi IRCCS, Florence, Italy

[21] Univ Cattolica Sacro Cuore, Div Thorac Surg, I-00168 Rome, Italy

[22] Univ London Imperial Coll Sci Technol & Med, Div Surg & Canc, Biosurg & Surg Technol Sect, London, England

[23] San Raffaele Montecompatri, Psychiat Unit, Montecompatri, RM, Italy

[24] IRCCS Arcispedale Santa Maria Nuova, Unit Thorac Surg, Reggio Emilia, Italy

[25] Osped Spirito Santo, Dept Thorac Surg, Pescara, Italy

[26] Biomax Informat AG, Planegg, Germany

[27] CFO Florence Canc Ctr, Sesto Fiorentino, Italy

[28] Univ Cattolica Sacro Cuore, Dept Geriatr Neurosci & Orthoped, Res Ctr Neuropsychol, I-00168 Rome, Italy

[29] Italian Syst Soc, Milan, Italy

[30] IRCCS San Raffaele Pisana, Dept Pulm Rehabil, Rome, Italy

[31] Unit San Raffaele Montecompatri, Montecompatri, RM, Italy

[32] Univ Grenoble 1, Inserm1055, Clin Univ Pneumol, Pole Cancerol Med Aigue & Communautaire,CHU Greno, Grenoble, France

[33] EISBM, Lyon, France

[34] San Filippo Neri Hosp, Clin Res Ctr & Cardiovasc Dept, Rome, Italy

[35] Univ Barcelona, Serv Pneumol, Thorax Inst, Hosp Clin,IDIBPAPS,CIBERES, Barcelona, Spain

[36] IRCCS San Raffaele Pisana, Dept Cardiovasc Res, Rome, Italy

[37] Catholic Univ, Inst Neurol, Dept Geriatr Neurosci Orthopaed Physiat, Rome, Italy

[38] IRCSS S Raffaele Pisana, Rome, Italy

[39] Casa Cura S Raffaele Cassino, Rome, Italy

[40] Hebrew Univ Jerusalem, Dept Biol Chem, Jerusalem, Israel

[41] Univ Amsterdam, Acad Med Ctr, NL-1012 WX Amsterdam, Netherlands

[42] IRCCS San Raffaele Pisana, Dept Med Sci, Cardiovasc Res Unit, Rome, Italy

[43] Maastricht Univ, Med Ctr, Dept Resp Med, Maastricht, Netherlands

来源：

CURRENT PHARMACEUTICAL DESIGN | 2014年 / 20卷 / 38期

关键词：

Systems medicine; non-communicable diseases; P4; medicine; systems biology; HEALTH SURVEY SF-36; PARKINSONS-DISEASE; RATING-SCALE; KNOWLEDGE MANAGEMENT; MOLECULAR NETWORKS; P4; MEDICINE; BIOLOGY; RELIABILITY; FORM; QUESTIONNAIRE;

D O I：

10.2174/1381612820666140314130449

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Non-Communicable Diseases (NCDs) are among the most pressing global health problems of the twenty-first century. Their rising incidence and prevalence is linked to severe morbidity and mortality, and they are putting economic and managerial pressure on healthcare systems around the world. Moreover, NCDs are impeding healthy aging by negatively affecting the quality of life of a growing number of the global population. NCDs result from the interaction of various genetic, environmental and habitual factors, and cluster in complex ways, making the complex identification of resulting phenotypes not only difficult, but also a top research priority. The degree of complexity required to interpret large patient datasets generated by advanced high-throughput functional genomics assays has now increased to the point that novel computational biology approaches are essential to extract information that is relevant to the clinical decision-making process. Consequently, system-level models that interpret the interactions between extensive tissues, cellular and molecular measurements and clinical features are also being created to identify new disease phenotypes, so that disease definition and treatment are optimized, and novel therapeutic targets discovered. Likewise, Systems Medicine (SM) platforms applied to extensively-characterized patients provide a basis for more targeted clinical trials, and represent a promising tool to achieve better prevention and patient care, thereby promoting healthy aging globally. The present paper: (1) reviews the novel systems approaches to NCDs; (2) discusses how to move efficiently from Systems Biology to Systems Medicine; and (3) presents the scientific and clinical background of the San Raffaele Systems Medicine Platform.

引用

页码：5945 / 5956

页数：12

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