Feasibility of intensity-modulated and image-guided radiotherapy for locally advanced esophageal cancer

被引：10

作者：

Nguyen, Nam P. ^{[1
]}

Jang, Siyoung ^{[9
]}

Vock, Jacqueline ^{[2
]}

Vincent Vinh-Hung ^{[3
]}

Chi, Alexander ^{[4
]}

Vos, Paul ^{[5
]}

Pugh, Judith ^{[6
]}

Vo, Richard A. ^{[7
]}

Ceizyk, Misty ^{[9
]}

Desai, Anand ^{[8
]}

Smith-Raymond, Lexie ^{[9
]}

机构：

[1] Howard Univ Hosp, Dept Radiat Oncol, Washington, DC 20060 USA

[2] Lindenhofspital, Dept Radiat Oncol, Bern, Switzerland

[3] Univ Hosp Geneva, Dept Radiat Oncol, Geneva, Switzerland

[4] W Virginia Univ, Dept Radiat Oncol, Morgantown, WV 26506 USA

[5] E Carolina Univ, Dept Biostat, Greenville, NC USA

[6] Univ Arizona, Dept Pathol, Tucson, AZ USA

[7] Univ Virginia, Dept Pediat, Charlottesville, VA USA

[8] Akron City Hosp, Dept Radiat Oncol, Akron, OH USA

[9] Univ Arizona, Dept Radiat Oncol, Tucson, AZ 85721 USA

来源：

BMC CANCER | 2014年 / 14卷

关键词：

Esophageal cancer; Tomotherapy; Normal tissue sparing; SQUAMOUS-CELL CARCINOMA; CONCURRENT CHEMORADIOTHERAPY; ADAPTIVE RADIOTHERAPY; HELICAL TOMOTHERAPY; ADVANCED HEAD; TOXICITY; NECK; CHEMORADIATION; CHEMOTHERAPY; SURGERY;

D O I：

10.1186/1471-2407-14-265

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: In this study the feasibility of intensity-modulated radiotherapy (IMRT) and tomotherapy-based image-guided radiotherapy (IGRT) for locally advanced esophageal cancer was assessed. Methods: A retrospective study of ten patients with locally advanced esophageal cancer who underwent concurrent chemotherapy with IMRT (1) and IGRT (9) was conducted. The gross tumor volume was treated to a median dose of 70 Gy (62.4-75 Gy). Results: At a median follow-up of 14 months (1-39 months), three patients developed local failures, six patients developed distant metastases, and complications occurred in two patients (1 tracheoesophageal fistula, 1 esophageal stricture requiring repeated dilatations). No patients developed grade 3-4 pneumonitis or cardiac complications. Conclusions: IMRT and IGRT may be effective for the treatment of locally advanced esophageal cancer with acceptable complications.

引用

页数：7

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