Stereoselective aldol reaction catalyzed by a highly recyclable polystyrene supported substituted prolinamide catalyst

被引：25

作者：

Gruttadauria, Michelangelo ^{[1
]}

Giacalone, Francesco ^{[1
]}

Marculescu, Adriana Mossuto ^{[1
]}

Salvo, Anna Maria Pia ^{[1
]}

Noto, Renato ^{[1
]}

机构：

[1] Univ Palermo, Dipartimento Chim Organ E Paterno, Viale Sci,Pad 17, I-90128 Palermo, Italy

来源：

ARKIVOC | 2009年

关键词：

organocatalysis; proline; aldol reaction; polystyrene; ASYMMETRIC ALDOL; ENANTIOSELECTIVE ALDOL; ORGANOCATALYST; EFFICIENT; WATER; KETONES;

D O I：

10.3998/ark.5550190.0010.802

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Polystyrene supported substituted prolinamide was used as catalyst in the aldol reaction between cyclohexanone or acetone and several substituted benzaldehydes in chloroform/water. This catalyst afforded aldol products in high yields and stereoselectivities, especially in the case of reactions performed with acetone. The catalyst was easily recovered by filtration and reused, after regeneration with formic acid, up to 22 times.

引用

页码：5 / 15

页数：11

共 59 条

[1] An effective heterogeneous L-proline catalyst for the asymmetric aldol reaction using anionic clays as intercalated support [J].