Hearing impairment in type 2 diabetics and patients with early diabetic nephropathy

被引:21
作者
Ren, Jianmin [1 ,2 ,3 ]
Ma, Fufu [1 ,2 ,3 ]
Zhou, Yujing [1 ,2 ,3 ]
Xu, Anting [4 ]
Zhang, Jianjian [1 ,2 ,3 ,5 ]
Ma, Rong [1 ,2 ,3 ]
Xiao, Xiaoyan [6 ]
机构
[1] Shandong Univ, Qilu Hosp, Dept Endocrinol, Jinan, Shandong, Peoples R China
[2] Shandong Univ, Inst Endocrinol & Metab, Jinan, Shandong, Peoples R China
[3] Shandong Prov Med & Hlth, Key Lab Endocrinol & Metab, Jinan, Shandong, Peoples R China
[4] Shandong Univ, Hosp 2, Dept Otolaryngol, Jinan, Shandong, Peoples R China
[5] Second Peoples Hosp Jinan, Dept Internal Med, Jinan, Shandong, Peoples R China
[6] Shandong Univ, Qilu Hosp, Dept Nephrol, 107 Wenhua Xi Rd, Jinan 250012, Shandong, Peoples R China
基金
中国博士后科学基金;
关键词
Type 2 diabetes mellitus; Diabetic nephropathy; Hearing impairment; Vestibular function; Otoacoustic emissions; INNER-EAR; MELLITUS; INSULIN;
D O I
10.1016/j.jdiacomp.2018.03.014
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aims: The study was to investigate the hearing function in subjects with non-diabetic nephropathy and diabetic nephropathy and analyze related clinical indexes of hearing impairment. Methods: We assessed the hearing function of 30 diabetics (DM group), 30 patients with early diabetic nephropathy (DN group) and 30 healthy subjects (NC group) using pure-tone audiometry, otoacoustic emissions, electronystagmography, caloric test and cervical vestibular evoked myogenic potential (VEMP). Results: Pure-tone audiogram demonstrated a deficit at frequencies with elevated threshold in both DM and DN group (p < 0.05). DN group showed a significant deficit with elevated threshold at 250, 8000 Hz in left ear and 8000 Hz in right ear compared to those of DM group (p < 0.05). GHbA1c, waist and ACR were correlated with elevated thresholds. The DPOAE amplitudes of DN group were obviously smaller in the left ear (4 kHz) and right ear (0.75, 2, 4 kHz) while those of DM group were significantly smaller in the right ear (0.75, 4 kHz) than controls (p < 0.05). A larger proportion of subjects with vestibular dysfunction and VEMP response absence were observed in DN group. Conclusions: Type 2 DM and DN patients have shown clinical hearing impairment and vestibular dysfunction. GHbA1c, waist, ACR, BMI, TC and diabetic retinopathy may affect hearing and vestibular function. (C) 2018 Elsevier Inc. All rights reserved.
引用
收藏
页码:575 / 579
页数:5
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