Inventory and function of yeast ABC proteins: about sex, stress, pleiotropic drug and heavy metal resistance

被引：225

作者：

Bauer, BE ^{[1
]}

Wolfger, H ^{[1
]}

Kuchler, K ^{[1
]}

机构：

[1] Univ & Bio Ctr Vienna, Dept Mol Genet, A-1030 Vienna, Austria

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 1999年 / 1461卷 / 02期

基金：

奥地利科学基金会;

关键词：

fungus; ABC protein; PDR network; gene regulation; antifungal drug resistance; pathogen; pheromone secretion; organelle; stress response; cellular detoxification;

D O I：

10.1016/S0005-2736(99)00160-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Saccharomyces cerevisiae was the first eukaryotic organism whose complete genome sequence has been determined, uncovering the existence of numerous genes encoding proteins of the ATP-binding cassette (ABC) family. Fungal ABC proteins are implicated in a variety of cellular functions, ranging from clinical drug resistance development, pheromone secretion, mitochondrial function, peroxisome biogenesis, translation elongation, stress response to cellular detoxification. Moreover, some yeast ABC proteins are orthologues of human disease genes, which makes yeast an excellent model system to study the molecular mechanisms of ABC protein-mediated disease. This review provides a comprehensive discussion and update on the function and transcriptional regulation of all known ABC genes from yeasts, including those discovered in fungal pathogens. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：217 / 236

页数：20

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