Inventory and function of yeast ABC proteins: about sex, stress, pleiotropic drug and heavy metal resistance

被引：225

作者：

Bauer, BE ^{[1
]}

Wolfger, H ^{[1
]}

Kuchler, K ^{[1
]}

机构：

[1] Univ & Bio Ctr Vienna, Dept Mol Genet, A-1030 Vienna, Austria

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 1999年 / 1461卷 / 02期

基金：

奥地利科学基金会;

关键词：

fungus; ABC protein; PDR network; gene regulation; antifungal drug resistance; pathogen; pheromone secretion; organelle; stress response; cellular detoxification;

D O I：

10.1016/S0005-2736(99)00160-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Saccharomyces cerevisiae was the first eukaryotic organism whose complete genome sequence has been determined, uncovering the existence of numerous genes encoding proteins of the ATP-binding cassette (ABC) family. Fungal ABC proteins are implicated in a variety of cellular functions, ranging from clinical drug resistance development, pheromone secretion, mitochondrial function, peroxisome biogenesis, translation elongation, stress response to cellular detoxification. Moreover, some yeast ABC proteins are orthologues of human disease genes, which makes yeast an excellent model system to study the molecular mechanisms of ABC protein-mediated disease. This review provides a comprehensive discussion and update on the function and transcriptional regulation of all known ABC genes from yeasts, including those discovered in fungal pathogens. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：217 / 236

页数：20

共 217 条

[1] Molecular biology of adenosine triphosphate-sensitive potassium channels [J].

Aguilar-Bryan, L ;

Bryan, J .

ENDOCRINE REVIEWS, 1999, 20 (02) :101-135

[2] The bZip transcription factor Cap1p is involved in multidrug resistance and oxidative stress response in Candida albicans [J].

Alarco, AM ;

Raymond, M .

JOURNAL OF BACTERIOLOGY, 1999, 181 (03) :700-708

[3] AP1-mediated multidrug resistance in Saccharomyces cerevisiae requires FLR1 encoding a transporter of the major facilitator superfamily [J].

Alarco, AM ;

Balan, I ;

Talibi, D ;

Mainville, N ;

Raymond, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (31) :19304-19313

[4] A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy (vol 15, pg 236, 1997) [J].

Allikmets, R .

NATURE GENETICS, 1997, 17 (01) :122-122

[5] Mutation of a putative mitochondrial iron transporter gene (ABC7) in X-linked sideroblastic anemia and ataxia (XLSA/A) [J].

Allikmets, R ;

Raskind, WH ;

Hutchinson, A ;

Schueck, ND ;

Dean, M ;

Koeller, DM .

HUMAN MOLECULAR GENETICS, 1999, 8 (05) :743-749

[6]

Allikmets R, 1998, CANCER RES, V58, P5337

[7] Expression of atrC -: encoding a novel member of the ATP binding cassette transporter family in Aspergillus nidulans -: is sensitive to cycloheximide [J].

Angermayr, K ;

Parson, W ;

Stöffler, G ;

Haas, H .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1999, 1453 (02) :304-310

[8] ADRENOLEUKODYSTROPHY GENE - UNEXPECTED HOMOLOGY TO A PROTEIN INVOLVED IN PEROXISOME BIOGENESIS [J].

AUBOURG, P ;

MOSSER, J ;

DOUAR, AM ;

SARDE, CO ;

LOPEZ, J ;

MANDEL, JL .

BIOCHIMIE, 1993, 75 (3-4) :293-302

[9] ADRENOLEUKODYSTROPHY AND OTHER PEROXISOMAL DISEASES [J].

AUBOURG, P .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 1994, 4 (03) :407-411

[10] The Candida albicans CDR3 gene codes for an opaque-phase ABC transporter [J].

Balan, I ;

Alarco, AM ;

Raymond, M .

JOURNAL OF BACTERIOLOGY, 1997, 179 (23) :7210-7218

← 1 2 3 4 5 6 7 8 9 10 →