Influence of PAMAM dendrimers on human red blood cells

被引：127
作者：
Domanski, DM [1 ]
Klajnert, B [1 ]
Bryszewska, M [1 ]
机构：
[1] Univ Lodz, Inst Biophys, Dept Gen Biophys, PL-90237 Lodz, Poland
来源：
BIOELECTROCHEMISTRY | 2004年 / 63卷 / 1-2期
关键词：
PAMAM dendrimers; erythrocytes; morphology; haemolysis; toxicity;
D O I：
10.1016/j.bioelechem.2003.09.023
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Polyamidoamine (PAMAM) dendrimers with different concentrations (1 nM-1 mM) (generations 2, 3, and 4) impact on human red blood cell morphology, and membrane integrity is studied. Erythrocyte shape changes from biconcave to echinocytic in dendrimers. Cell aggregation occurs. Polymers cause also concentration- and generation-dependent haemolysis. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：189 / 191
页数：3
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