Immobilized transferrin Fe3O4@SiO2 nanoparticle with high doxorubicin loading for dual-targeted tumor drug delivery

被引：42
作者：
Ding, Wence [1 ]
Guo, Lin [1 ]
机构：
[1] Nanjing Univ, Sch Chem & Chem Engn, Minist Educ, Key Lab Mesoscop Chem, Nanjing 210093, Jiangsu, Peoples R China
来源：
INTERNATIONAL JOURNAL OF NANOMEDICINE | 2013年 / 8卷
关键词：
transferrin; Fe3O4@SiO2; nanoparticle; doxorubicin; targeted tumor; MAGNETIC NANOPARTICLES; RECEPTOR; CANCER; RELEASE; CELLS; CARDIOMYOPATHY; ANTHRACYCLINES; MICROSPHERES; ADRIAMYCIN; SYSTEM;
D O I：
10.2147/IJN.S51745
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Transferrin (Tf) was immobilized onto Fe3O4@SiO2 nanoparticles with high doxorubicin (DOX) loading (TfDMP), for dual targeting of cancer, by chemically coupling both Tf and DOX with dual-function magnetic nanoparticles (DMPs) using a multi-armed crosslinker, poly-L-glutamic acid. With high trapping efficiency for magnetic targeting, TfDMP exhibits a Tf receptor-targeting function. Moreover, the DOX loading percentage of TfDMP is high, and can be controlled by adjusting the reactant ratio. TfDMP presents a narrow size distribution, and is sensitive to pH for drug release. Compared with DOX-coupled DMP without Tf modification (DDMP), TfDMP exhibits enhanced uptake by Tf receptor-expressing tumor cells, and displays stronger cancer cell cytotoxicity. This study provides an efficient method for the dual-targeted delivery of therapeutic agents to tumors, with controlled low carrier toxicity and high efficiency.
引用
收藏
页码：4631 / 4638
页数：8
相关论文
共 35 条
  • [1] Alexiou C, 2000, CANCER RES, V60, P6641
  • [2] Drug delivery systems: Entering the mainstream
    Allen, TM
    Cullis, PR
    [J]. SCIENCE, 2004, 303 (5665) : 1818 - 1822
  • [3] Magnetic nanoparticles for drug delivery
    Arruebo, Manuel
    Fernandez-Pacheco, Rodrigo
    Ibarra, M. Ricardo
    Santamaria, Jesus
    [J]. NANO TODAY, 2007, 2 (03) : 22 - 32
  • [4] In vivo heating of magnetic nanoparticles in alternating magnetic field
    Babincová, M
    Altanerová, V
    Altaner, C
    Cicmanec, P
    Babinec, P
    [J]. MEDICAL PHYSICS, 2004, 31 (08) : 2219 - 2221
  • [5] The calculation of the dosage-mortality curve
    Bliss, CI
    [J]. ANNALS OF APPLIED BIOLOGY, 1935, 22 (01) : 134 - 167
  • [6] Doxorubicin Release Triggered by Alginate Embedded Magnetic Nanoheaters: A Combined Therapy
    Brule, Severine
    Levy, Michael
    Wilhelm, Claire
    Letourneur, Didier
    Gazeau, Florence
    Menager, Christine
    Le Visage, Catherine
    [J]. ADVANCED MATERIALS, 2011, 23 (06) : 787 - +
  • [7] Anti-cancer activity of an acid-labile N-alkylisatin conjugate targeting the transferrin receptor
    Chandran, Vineesh Indira
    Matesic, Lidia
    Locke, Julie M.
    Skropeta, Danielle
    Ranson, Marie
    Vine, Kara L.
    [J]. CANCER LETTERS, 2012, 316 (02) : 151 - 156
  • [8] Transferrin-conjugated boron nitride nanotubes: Protein grafting, characterization, and interaction with human endothelial cells
    Ciofani, Gianni
    Del Turco, Serena
    Genchi, Giada Graziana
    D'Alessandro, Delfo
    Basta, Giuseppina
    Mattoli, Virgilio
    [J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2012, 436 (1-2) : 444 - 453
  • [9] The transferrin receptor part I: Biology and targeting with cytotoxic antibodies for the treatment of cancer
    Daniels, Tracy R.
    Delgado, Tracie
    Rodriguez, Jose A.
    Helguera, Gustavo
    Penichet, Manuel L.
    [J]. CLINICAL IMMUNOLOGY, 2006, 121 (02) : 144 - 158
  • [10] The transferrin receptor part II: Targeted delivery of therapeutic agents into cancer cells
    Daniels, Tracy R.
    Delgado, Tracie
    Helguera, Gustavo
    Penichet, Manuel L.
    [J]. CLINICAL IMMUNOLOGY, 2006, 121 (02) : 159 - 176
1234