Isoplatensimycin: Synthesis and biological evaluation

被引：32
|
作者：
Jang, Ki Po [1 ]
Kim, Chan Hyuk [1 ]
Na, Seong Wook [1 ]
Kim, Hiyoung [2 ]
Kang, Heonjoong [2 ]
Lee, Eun [1 ]
机构：
[1] Seoul Natl Univ, Coll Nat Sci, Dept Chem, Seoul 151747, South Korea
[2] Seoul Natl Univ, Coll Nat Sci, Sch Earth & Environm Sci, Seoul 151747, South Korea
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 16期
关键词：
Antibiotic; Platensimycin; Isoplatensimycin; FORMAL SYNTHESIS; ENANTIOSELECTIVE ROUTE; PLATENSIMYCIN ANALOGS; OXATETRACYCLIC CORE;
D O I：
10.1016/j.bmcl.2009.06.092
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Isoplatensimycin, a novel analog of platensimycin, was synthesized via intramolecular dipolar cycloaddition of a carbonyl ylide. Isoplatensimycin showed little activities against strains of Staphylococcus aureus, but exhibited activities against some vancomycin-resistant enteroccoci. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4601 / 4602
页数：2
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