Synthesis and Biological Evaluation of New Hydrazone Derivatives of Quinoline and Their Cu(II) and Zn(II) Complexes against Mycobacterium tuberculosis

被引：50
|
作者：
Mandewale, Mustapha C. [1 ]
Thorat, Bapu [1 ]
Shelke, Dnyaneshwar [1 ]
Yamgar, Ramesh [2 ]
机构：
[1] Govt Maharashtra, Ismail Yusuf Coll Arts Sci & Commerce, Dept Chem, PG & Res Ctr, Bombay 400060, Maharashtra, India
[2] Chikitsak Samuhas Patkar Varde Coll Arts Sci & Co, Dept Chem, Bombay 400062, Maharashtra, India
来源：
BIOINORGANIC CHEMISTRY AND APPLICATIONS | 2015年 / 2015卷
关键词：
SCHIFF-BASES; RESISTANT TUBERCULOSIS; ANTIBACTERIAL ACTIVITY; RIFAMPIN-RESISTANT;
D O I：
10.1155/2015/153015
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A new series of quinoline hydrazone derivatives and their metal complexes have been synthesized and their biological properties have been evaluated against Mycobacterium tuberculosis (H37 RV strain). Most of the newly synthesized compounds displayed 100% inhibitory activity at a concentration of 6.25-25 mu g/mL, against Mycobacterium tuberculosis. Fluorescence properties of all the synthesized compounds have been studied.
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页数：14
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