Sulfur dioxide, a double-faced molecule in mammals

被引：110
作者：
Wang, Xin-Bao [1 ]
Du, Jun-Bao [2 ]
Cui, Hong [1 ]
机构：
[1] Capital Med Univ, Beijing Friendship Hosp, Dept Pediat, Beijing 100050, Peoples R China
[2] Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
来源：
LIFE SCIENCES | 2014年 / 98卷 / 02期
关键词：
Sulfur dioxide; Physiological effects; Pathophysiological effects; Biology; Gasotransmitter; OXIDATIVE DAMAGE; CARDIOVASCULAR-SYSTEM; HYDROGEN-SULFIDE; MICE; INHALATION; DERIVATIVES; MODULATION; INJURY; RATS; SO2;
D O I：
10.1016/j.lfs.2013.12.027
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Sulfur dioxide (SO2) is a common air pollutant and is detrimental to many organs. Its toxic effects including oxidative damage, deoxyribonucleic acid (DNA) damage and inflammation have been extensively studied. However, recent studies showed that SO2 can be generated endogenously in mammals. In contrast to the toxic effects of SO2, protective effects have also been found in mammals. Endogenous SO2 has antioxidant, anti-inflammatory, anti-hypertension, and anti-atherogenic effects and regulates vascular tone and cardiac function in mammals. SO2 may have a dual role in regulating physiological and pathophysiological effects in manimals. The biological effects of SO2 in mammals are reviewed in this study. (c) 2014 Elsevier Inc. All rights reserved.
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收藏
页码：63 / 67
页数：5
相关论文
共 35 条
[1]  
[Anonymous], 2013, BIOCHEM BIOPH RES CO, V433, P519
[2]   Sulfur dioxide attenuates LPS-induced acute lung injury via enhancing polymorphonuclear neutrophil apoptosis [J].
Ma, Hui-jie ;
Huang, Xin-li ;
Liu, Yan ;
Fan, Ya-min .
ACTA PHARMACOLOGICA SINICA, 2012, 33 (08) :983-990
[3]  
Meng Zi-qiang, 2007, Asian Journal of Ecotoxicology, V2, P158
[4]   Vasodilatation of sulfur dioxide derivatives and signal transduction [J].
Meng, Ziqiang ;
Li, Yi ;
Li, Junling .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2007, 467 (02) :291-296
[5]   The vasodilator effect and its mechanism of sulfur dioxide-derivatives on isolated aortic rings of rats [J].
Meng, Ziqiang ;
Zhang, Haifei .
INHALATION TOXICOLOGY, 2007, 19 (11) :979-986
[6]   Vasodilator effect of gaseous sulfur dioxide and regulation of its level by Ach in rat vascular tissues [J].
Meng, Ziqiang ;
Li, Junling ;
Zhang, Quanxi ;
Bai, Weiming ;
Yang, Zhenhua ;
Zhao, Ying ;
Wang, Faqi .
INHALATION TOXICOLOGY, 2009, 21 (14) :1223-1228
[7]   Effect of sulfur dioxide inhalation on cytokine levels in lungs and serum of mice [J].
Meng, ZQ ;
Liu, YX ;
Wu, DM .
INHALATION TOXICOLOGY, 2005, 17 (06) :303-307
[8]   Oxidation damage of sulfur dioxide on testicles of mice [J].
Meng, ZQ ;
Bai, W .
ENVIRONMENTAL RESEARCH, 2004, 96 (03) :298-304
[9]   Oxidative damage of sulfur dioxide inhalation on lungs and hearts of mice [J].
Meng, ZQ ;
Qin, GH ;
Zhang, B ;
Geng, H ;
Bai, QL ;
Bai, W ;
Liu, CY .
ENVIRONMENTAL RESEARCH, 2003, 93 (03) :285-292
[10]   Oxidative damage of sulfur dioxide inhalation on stomachs and intestines of mice [J].
Meng, ZQ ;
Zhang, B ;
Bai, JL ;
Geng, H ;
Liu, CY .
INHALATION TOXICOLOGY, 2003, 15 (04) :397-410
1234