Effect of contact force on breast tissue optical property measurements using a broadband diffuse optical spectroscopy handheld probe

被引：22

作者：

Cerussi, Albert ^{[1
]}

Siavoshi, Sarah ^{[1
]}

Durkin, Amanda ^{[1
]}

Chen, Cynthia ^{[1
]}

Tanamai, Wendy ^{[1
]}

Hsiang, David ^{[2
]}

Tromberg, Bruce J. ^{[1
]}

机构：

[1] Univ Calif Irvine, Laser Med & Microbeam Program, Beckman Laser Inst, Irvine, CA 92612 USA

[2] Univ Calif Irvine, Med Ctr, Chao Family Comprehens Canc Ctr, Div Surg Oncol, Orange, CA 92868 USA

来源：

APPLIED OPTICS | 2009年 / 48卷 / 21期

基金：

美国国家卫生研究院;

关键词：

NEOADJUVANT CHEMOTHERAPY; FREQUENCY-DOMAIN; MAMMOGRAPHY; HEMOGLOBIN; US;

D O I：

10.1364/AO.48.004270

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We investigated the effects of operator-applied force on diffuse optical spectroscopy (DOS) by integrating a force transducer into the handheld probe. Over the typical range of contact forces measured in the breasts of eight patients, absorption and reduced scattering coefficients (650 to 1000 nm) variance was 3.1 +/- 1.0% and 1.0 +/- 0.4%. For trained operators, we observed <5% variation in hemoglobin and <2% variation in water and lipids. Contact force is not a significant source of variation, most likely because of a relatively wide probe surface area and the stability of the DOS method for calculating tissue optical properties. (C) 2009 Optical Society of America

引用

页码：4270 / 4277

页数：8

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