Excellent correlation between substituent constants and pyridinium N-methyl chemical shifts

被引：19

作者：

Huang, Sha ^{[1
]}

Wong, Jesse C. S. ^{[1
]}

Leung, Adam K. C. ^{[1
]}

Chan, Yee Man ^{[1
]}

Wong, Lili ^{[1
]}

Fernendez, Myrien R. ^{[1
]}

Miller, Amanda K. ^{[1
]}

Wu, Weiming ^{[1
]}

机构：

[1] San Francisco State Univ, Dept Chem & Biochem, San Francisco, CA 94132 USA

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 35期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

D O I：

10.1016/j.tetlet.2009.06.081

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Substituents on the pyridinium ring of N-methylpyridinium derivatives, especially those on the 2- or 4-position, have a large effect on the H-1 and C-13 NMR chemical shifts of the N-methyl group. Reasonable correlations between the chemical shift changes and the resonance substituent constants are observed. The dual substituent parameter approach provides an excellent correlation when a combination of polar and resonance substituent constants is employed. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：5018 / 5020

页数：3

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