Effect of Spinal Manometers on Cerebrospinal Fluid Amyloid-β Concentration

被引：5
作者：
Toombs, Jamie [1 ]
Foiani, Martha S. [1 ]
Paterson, Ross W. [2 ]
Heslegrave, Amanda [1 ]
Wray, Selina [1 ]
Schott, Jonathan M. [2 ]
Fox, Nick C. [2 ]
Lunn, Michael P. [3 ]
Blennow, Kaj [4 ]
Zetterberg, Henrik [1 ,4 ]
机构：
[1] UCL, Inst Neurol, Dept Mol Neurosci, London WC1N 3BG, England
[2] Inst Neurol, Dementia Res Ctr, Dept Neurodegenerat, London, England
[3] UCL, Inst Neurol, Dept Neuroimmunol, London, England
[4] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Gothenburg, Sweden
来源：
JOURNAL OF ALZHEIMERS DISEASE | 2017年 / 56卷 / 03期
关键词：
Alzheimer's disease; amyloid-beta; biomarkers; cerebrospinal fluid; manometer; pre-analytical factor; ALZHEIMERS ASSOCIATION WORKGROUPS; PREANALYTICAL CONFOUNDING FACTORS; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; TAU-PROTEIN; DISEASE; RECOMMENDATIONS; BIOMARKERS; STORAGE; VARIABILITY;
D O I：
10.3233/JAD-161126
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effect of spinal manometers on cerebrospinal fluid (CSF) amyloid-beta (A beta) concentration was investigated. Pooled human CSF samples were divided in two, one half passed through a manometer into a collection tube, the other transferred directly to a collection tube. CSF was analyzed for A beta 38/40/42 using an electrochemiluminescence immunoassay. Relative to control, use of a manometer decreased A beta 38/40/42 concentration by 5.6% (+/- 1.5SE), 4.4% (+/- 1.7SE), and 4.3% (+/- 2.4SE), respectively. The ratios of A beta(42 : 40), A beta(42 : 38), and A beta(40 : 38) were not affected by manometer treatment. Factors which artificially lower CSF A beta concentrations are relevant to clinical diagnosis for AD and study design.
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收藏
页码：885 / 891
页数：7
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