Predicted sequence of cortical tau and amyloid-β deposition in Alzheimer disease spectrum

被引：35

作者：

Cho, Hanna ^{[1
]}

Lee, Hye Sun ^{[2
]}

Choi, Jae Yong ^{[3
,4
]}

Lee, Jae Hoon ^{[3
]}

Ryu, Young Hoon ^{[3
]}

Lee, Myung Sik ^{[1
]}

Lyoo, Chul Hyoung ^{[1
]}

机构：

[1] Yonsei Univ, Coll Med, Gangnam Severance Hosp, Dept Neurol, Seoul, South Korea

[2] Yonsei Univ, Coll Med, Biostat Collaborat Unit, Seoul, South Korea

[3] Yonsei Univ, Coll Med, Dept Nucl Med, Gangnam Severance Hosp, Seoul, South Korea

[4] Korea Inst Radiol & Med Sci, Div RI Convergence Res, Seoul, South Korea

来源：

NEUROBIOLOGY OF AGING | 2018年 / 68卷

基金：

新加坡国家研究基金会;

关键词：

Alzheimer disease; Tau; Amyloid-beta; PET; F-18-flortaucipir; MILD COGNITIVE IMPAIRMENT; PATHOLOGICAL PROCESS; HUMAN BRAIN; MODEL; PROPAGATION; DEMENTIA; PART; PET; DEGENERATION; PATTERN;

D O I：

10.1016/j.neurobiolaging.2018.04.007

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

We investigated sequential order between tau and amyloid-beta (A beta) deposition in Alzheimer disease spectrum using a conditional probability method. Two hundred twenty participants underwent F-18-flortaucipir and F-18-florbetaben positron emission tomography scans and neuropsychological tests. The presence of tau and A beta in each region and impairment in each cognitive domain were determined by Z-score cutoffs. By comparing pairs of conditional probabilities, the sequential order of tau and A beta deposition were determined. Probability for the presence of tau in the entorhinal cortex was higher than that of A beta in all cortical regions, and in the medial temporal cortices, probability for the presence of tau was higher than that of A beta. Conversely, in the remaining neocortex above the inferior temporal cortex, probability for the presence of A beta was always higher than that of tau. Tau pathology in the entorhinal cortex may appear earlier than neocortical A beta and may spread in the absence of A beta within the neighboring medial temporal regions. However, A beta may be required for massive tau deposition in the distant cortical areas. (C) 2018 Elsevier Inc. All rights reserved.

引用

页码：76 / 84

页数：9

共 43 条

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