Genetic control of MHC class II expression

被引：462

作者：

Ting, JPY ^{[1
]}

Trowsdale, J

机构：

[1] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[3] Univ Cambridge, Dept Pathol, Div Immunol, Cambridge CB2 1QP, England

[4] Cambridge Inst Med Res, Cambridge CB2 2XY, England

来源：

CELL | 2002年 / 109卷

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0092-8674(02)00696-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The presentation of peptides to T cells by MHC class II molecules is of critical importance in specific recognition by the immune system. Expression of class II molecules is exquisitely controlled at the transcriptional level. A large set of proteins interact with the promoters of class II genes. The most important of these is CIITA, a master controller that orchestrates expression but does not bind directly to the promoter. The transcriptosome complex formed at class II promoters is a model for induction of gene expression.

引用

页码：S21 / S33

页数：13

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