Autophagy as an immune defense mechanism

被引：169
作者：
Deretic, Vojo
机构：
[1] Univ New Mexico, Dept Mol Genet, Sch Med, Albuquerque, NM 87131 USA
[2] Univ New Mexico, Dept Microbiol, Sch Med, Albuquerque, NM 87131 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2006年 / 18卷 / 04期
关键词：
D O I：
10.1016/j.coi.2006.05.019
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Autophagy is a homeostatic process whereby cytosol or intracellular organelles are sequestered by a double membrane structure termed autophagosome for subsequent delivery to lysosomes and degradation. Autophagy takes part in cell survival and death and has been implicated in development, aging, neurodegeneration and cancer. The newly discovered specialized role of autophagy in immune cells expands autophagic functions to defense against intracellular pathogens. Furthermore, autophagy is involved in acquired immunity, such as antigen processing for MHC II presentation, and is modulated by cytokines such as IFN-gamma. A further link has emerged between autophagy and defense against intracellular pathogens via the immunity-related GTPase Irgm1 (LRG-47), which has a protective role against Mycobacterium tuberculosis. We propose the term immunophagy for these defense processes.
引用
收藏
页码：375 / 382
页数：8
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