Metastatic potential of lymphoma/leukemia cell lines in SCID mice is closely related to expression of CD44

被引：3

作者：

Kawasaki, N ^{[1
]}

Matsuo, Y ^{[1
]}

Yoshino, T ^{[1
]}

Yanai, H ^{[1
]}

Oka, T ^{[1
]}

Teramoto, N ^{[1
]}

Liu, C ^{[1
]}

Kondo, E ^{[1
]}

Minowada, J ^{[1
]}

Akagi, T ^{[1
]}

机构：

[1] HAYASHIBARA BIOCHEM LABS INC, FUJISAKI CELL BANK CTR, OKAYAMA 702, JAPAN

来源：

JAPANESE JOURNAL OF CANCER RESEARCH | 1996年 / 87卷 / 10期

关键词：

malignant lymphoma; adhesion molecule; Hermes-3; metastasis; animal model;

D O I：

10.1111/j.1349-7006.1996.tb03112.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To investigate whether the lymphocyte homing receptors, adhesion molecules regulating normal lymphocyte traffic, influence the dissemination of lymphoma cells, 24 lymphoma/leukemia cell lines were inoculated into SCID mice subcutaneously, and the correlation between the expression of the adhesion molecules and the metastatic potential of the cell lines was examined. Among the six adhesion molecules examined (LFA-1, ICAM-1, CLA, VLA-4, L-selectin and CD44), L-selectin increased the incidence of lymph node metastasis, and CD44 expression was related to both lymph node and organ (hematogenous) metastasis. A monoclonal antibody to the standard form of CD44 (CD44s), Hermes-3, inhibited the local growth and remote metastasis of CD44(+) cell lines. Thus, it is concluded that at least CD44s expression is important in both lymphatic and hematogenous metastasis.

引用

页码：1070 / 1077

页数：8

共 33 条

[1] AMINO-ACID-SEQUENCE OF THE HUMAN FIBRONECTIN RECEPTOR [J].

ARGRAVES, WS ;

SUZUKI, S ;

ARAI, H ;

THOMPSON, K ;

PIERSCHBACHER, MD ;

RUOSLAHTI, E .

JOURNAL OF CELL BIOLOGY, 1987, 105 (03) :1183-1190

[2] BINDING OF L-SELECTIN TO THE VASCULAR SIALOMUCIN CD34 [J].

BAUMHUETER, S ;

SINGER, MS ;

HENZEL, W ;

HEMMERICH, S ;

RENZ, M ;

ROSEN, SD ;

LASKY, LA .

SCIENCE, 1993, 262 (5132) :436-438

[3] COMPARISON OF L-SELECTIN AND E-SELECTIN LIGAND SPECIFICITIES - THE L-SELECTIN CAN BIND THE E-SELECTIN LIGANDS SIALYL LEX AND SIALYL LEA [J].

BERG, EL ;

MAGNANI, J ;

WARNOCK, RA ;

ROBINSON, MK ;

BUTCHER, EC .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 184 (02) :1048-1055

[4] HOMING RECEPTORS AND VASCULAR ADDRESSINS - CELL-ADHESION MOLECULES THAT DIRECT LYMPHOCYTE TRAFFIC [J].

BERG, EL ;

GOLDSTEIN, LA ;

JUTILA, MA ;

NAKACHE, M ;

PICKER, LJ ;

STREETER, PR ;

WU, NW ;

ZHOU, D ;

BUTCHER, EC .

IMMUNOLOGICAL REVIEWS, 1989, 108 :5-18

[5] L-SELECTIN-MEDIATED LYMPHOCYTE ROLLING ON MADCAM-1 [J].

BERG, EL ;

MCEVOY, LM ;

BERLIN, C ;

BARGATZE, RF ;

BUTCHER, EC .

NATURE, 1993, 366 (6456) :695-698

[6] THE CUTANEOUS LYMPHOCYTE ANTIGEN IS A SKIN LYMPHOCYTE HOMING RECEPTOR FOR THE VASCULAR LECTIN ENDOTHELIAL CELL-LEUKOCYTE ADHESION MOLECULE-1 [J].

BERG, EL ;

YOSHINO, T ;

ROTT, LS ;

ROBINSON, MK ;

WARNOCK, RA ;

KISHIMOTO, TK ;

PICKER, LJ ;

BUTCHER, EC .

JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 174 (06) :1461-1466

[7]

BUTCHER EC, 1986, CURR TOP MICROBIOL, V128, P85

[8] LEUKOCYTE-ENDOTHELIAL CELL RECOGNITION - 3 (OR MORE) STEPS TO SPECIFICITY AND DIVERSITY [J].

BUTCHER, EC .

CELL, 1991, 67 (06) :1033-1036

[9]

CARLOS TM, 1994, BLOOD, V84, P2068

[10] VCAM-1 ON ACTIVATED ENDOTHELIUM INTERACTS WITH THE LEUKOCYTE INTEGRIN VLA-4 AT A SITE DISTINCT FROM THE VLA-4 FIBRONECTIN BINDING-SITE [J].

ELICES, MJ ;

OSBORN, L ;

TAKADA, Y ;

CROUSE, C ;

LUHOWSKYJ, S ;

HEMLER, ME ;

LOBB, RR .

CELL, 1990, 60 (04) :577-584

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