Uncoupling Protein 2 and Peroxisome Proliferator-Activated Receptor γ Gene Polymorphisms in Association with Diabetes Susceptibility in Chinese Han Population with Variant Glucose Tolerance

Objective. To investigate the association of polymorphisms in uncoupling protein 2 (UCP2) and peroxisome proliferator-activated receptor (PPAR.) with glucolipid metabolism in Chinese Han population. Methods. Five hundred eighty-nine subjects were divided into normal glucose tolerance (NGT) group (n = 198) and abnormal glucose tolerance group (n = 358). HbA1c, blood lipid profile, plasma glucose, and insulin were determined. Insulin sensitivity (HOMA-IR and Matsuda index (ISIM)) and insulin secretion indexes (HOMA-beta, early and total phase disposition index) were evaluated. Eight potential functional SNPs in UCP2 and 7 in PPAR. were selected. SNPs were genotyped on Sequenom MassARRAY platform. Results. The GG genotype of rs2920502 in PPAR. was associated with decreased risk of impaired glucose tolerance (G allele: OR: 0.818, 95% CI: 0.526-0.969, P = 0 042; GG: OR: 0.715, 95% CI: 0.527-0.97, P = 0 031). The TT genotype of rs3856806 in PPAR. was associated with increased risk of impaired glucose tolerance (T allele: OR: 1.46, 95% CI: 1.055-2.017, P = 0 022; TT: OR: 1.58, 95% CI: 1.104-2.761, P = 0 032). The GG genotype of rs2920502 in PPAR. had better blood glucose and increased insulin secretion and had lower HOMA-IR than GC/CC genotypes. Conclusion. It probably could prevent insulin resistance in early stage by classifying the genotype of rs649446 and rs7109266 in UCP2. The GG genotype of rs2920502 in PPAR. had a decreased risk for diabetes. The TT genotype of rs3856806 in PPAR. had an increased risk for diabetes.