Towing of sensory axons by their migrating target cells in vivo

被引：93

作者：

Gilmour, D

Knaut, H

Maischein, HM

Nüsslein-Volhard, C

机构：

[1] Max Planck Inst Entwicklungsbiol, Genet Abt, D-72076 Tubingen, Germany

[2] NYU, Sch Med, Dev Genet Program, Skirball Inst Biomol Med, New York, NY 10016 USA

来源：

NATURE NEUROSCIENCE | 2004年 / 7卷 / 05期

关键词：

D O I：

10.1038/nn1235

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Many pathfinding axons must locate target fields that are themselves positioned by active migration. A hypothetical method for ensuring that these migrations are coordinated is towing, whereby the extension of axons is entirely dependent on the migration of their target cells. Here we combine genetics and time-lapse imaging in the zebrafish to show that towing by migrating cells is a bona fide mechanism for guiding pathfinding axons in vivo.

引用

收藏

页码：491 / 492

页数：2

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