Transformation from follicular lymphoma to high-grade B-cell lymphoma/leukemia with additional t(2;8)(p12;q24), with inverse expressions of c-MYC and BCL-2, and light-chain switch

被引：7

作者：

Mannouji, Kiyohito ^{[2
]}

Tasaka, Taizo ^{[3
]}

Akiyama, Takashi ^{[1
]}

Irei, Isao ^{[1
]}

Sano, Fuminori ^{[2
]}

Matsuhashi, Yoshiko ^{[2
]}

Wada, Hideho ^{[2
]}

Tohyama, Kaoru ^{[3
]}

Sugihara, Takashi ^{[2
]}

Sadahira, Yoshito ^{[1
]}

机构：

[1] Kawasaki Med Sch, Dept Pathol, Kurashiki, Okayama 7010192, Japan

[2] Kawasaki Med Sch, Div Hematol, Dept Med, Kurashiki, Okayama 7010192, Japan

[3] Kawasaki Med Sch, Dept Clin Pathol & Lab Med, Kurashiki, Okayama 7010192, Japan

来源：

PATHOLOGY INTERNATIONAL | 2009年 / 59卷 / 04期

关键词：

BCL-2; Burkitt lymphoma; c-MYC; follicular lymphoma; transformation; ACUTE LYMPHOBLASTIC-LEUKEMIA; TRANSLOCATIONS; T(14-18);

D O I：

10.1111/j.1440-1827.2009.02361.x

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Transformation from follicular lymphoma (FL) to high-grade B-cell lymphoma/leukemia (BLL) has been reported in patients with additional translocations involving the c-MYC gene. The previously reported cases were related to t(8;14) and t(8;22) but not to t(2;8). Herein is reported an FL that terminated in BLL following additional t(2;8). In accordance with previous reports, increased expression of c-MYC was observed in the present case but, interestingly, BCL-2 expression was inversely decreased after the transformation. In addition, the cell-surface immunoglobulin light-chain of lymphoma cells was initially kappa type and was then gradually replaced with the lambda type after transformation. Downregulation of BCL-2 and light-chain switch have rarely been reported in previous cases of FL transformation involving c-MYC, suggesting that additional t(2;8) translocation may play a role in these events.

引用

页码：261 / 264

页数：4

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