Cost of hospitalization for aneurysmal subarachnoid hemorrhage in the United States

Objective: Recent large-scale studies describing hospitalization cost trends secondary to aneurysmal sub-arachnoid hemorrhage (aSAH) in the United States are lacking. We sought to discover the impact of aSAH-related factors upon its hospitalization cost. Patients and methods: Patients with a primary diagnosis of aSAH were selected utilizing the National Inpatient Sample. Regression analyses were used to evaluate the impact of aSAH-related factors on hospitalization costs. Results: From 2002-2014, 22,831 cases of aSAH were identified. The inflation-adjusted mean cost of hospitalization was $82,514 (standard deviation +/- $54,983). The proportion of males was lower (31%), but a higher cost of $3385 (+/- $685; p < .001) remained compared to females. Median length of hospitalization was 16 days (interquartile range 11-23) and each day increase in hospitalization was associated with a cost increase of $3228 (+/- $19; p < .001). There was no difference in cost between patients undergoing aneurysmal coiling or clipping. When compared to patients < 40 years old, the increase in cost for patients 40-59 years old was $3829 (+/- $914; p < .001), and $4573 (+/- $1033; p < .001) for patients 60-79 years old; however, for patients >= 80 years old, there was a decrease in cost of $8124 (+/- $1722; p < .001). Several central nervous system complications were also associated with increased cost. Conclusion: aSAH is a significant financial burden on the United States healthcare system. We were able to identify many important factors associated with higher costs, and these results may help us understand resource utilization and develop future cost-reduction strategies.