One-pot synthesis of 2-substituted quinoxalines using K10-montmorillonite as heterogeneous catalyst

被引：38

作者：

Jeganathan, Mariappan ^{[1
]}

Dhakshinamoorthy, Amarajothi ^{[1
,2
]}

Pitchumani, Kasi ^{[1
,2
]}

机构：

[1] Madurai Kamaraj Univ, Sch Chem, Madurai 625021, Tamil Nadu, India

[2] Madurai Kamaraj Univ, Sch Chem, Ctr Green Chem Proc, Madurai 625021, Tamil Nadu, India

来源：

TETRAHEDRON LETTERS | 2014年 / 55卷 / 09期

关键词：

Quinoxalines; K10-montmorillonite; Solid acids; 1,2-Diamines; alpha-Bromoketones; SOLID-PHASE SYNTHESIS; TANDEM OXIDATION; EFFICIENT SYNTHESIS; SOLVENT-FREE; DERIVATIVES; INHIBITORS; PROTOCOL; KETONES; CLAYS; WATER;

D O I：

10.1016/j.tetlet.2014.01.087

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient one-pot synthesis of 2-substituted quinoxalines from 1,2-diamines and phenacyl bromides is developed using K10-montmorillonite (K10 clay) as a catalyst at 50 degrees C in acetonitrile medium. This method offers an easy route for the synthesis of substituted quinoxalines in high yields. A plausible mechanism is proposed in which quinoxalines are formed via dehydration-dehydrohalogenationcyclization sequence. Further, the K10 clay catalyst is recovered by simple filtration and reused six times without any loss in its catalytic activity. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：1616 / 1620

页数：5

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