Is the Interleukin 8 Promoter Polymorphism rs4073/-251T >A Associated With Clostridium difficile Infection?

被引：6
|
作者：
Miyajima, Fabio [1 ,2 ]
Swale, Andrew [1 ,2 ]
Zhang, J. Eunice [1 ]
Alfirevic, Ana [1 ]
Little, Margaret [1 ,2 ]
Beeching, Nicholas J. [2 ,3 ]
Smith, Godfrey [2 ]
Kolamunnage-Dona, Ruwanthi [4 ]
Pirmohamed, Munir [1 ,2 ]
机构：
[1] Univ Liverpool, Wolfson Ctr Personalised Med, Liverpool L69 3GL, Merseyside, England
[2] Royal Liverpool & Broadgreen Univ Hosp NHS Trust, Liverpool, Merseyside, England
[3] Univ Liverpool Liverpool Sch Trop Med, Liverpool, Merseyside, England
[4] Univ Liverpool, Dept Biostat, Liverpool L69 3BX, Merseyside, England
来源：
CLINICAL INFECTIOUS DISEASES | 2014年 / 58卷 / 12期
基金：
美国国家卫生研究院; 英国医学研究理事会;
关键词：
Clostridium difficile; genetic predisposition; interleukin; 8; host response; meta-analysis; COMMON POLYMORPHISM; GENE PROMOTER; DIARRHEA; PATHOGENICITY; INFLAMMATION; COLITIS;
D O I：
10.1093/cid/ciu152
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The interleukin 8 gene single-nucleotide polymorphism rs4073/-251T >A predisposes to Clostridium difficile infection (CDI), but this association has not been independently validated. In this study, we were unable to replicate this association in either a white cohort or by meta-analysis, suggesting that rs4073/-251T >A is unlikely to constitute a major risk factor for CDI.
引用
收藏
页码：E148 / E151
页数：4
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