Longitudinal Analysis of Raltegravir Susceptibility and Integrase Replication Capacity of Human Immunodeficiency Virus Type 1 during Virologic Failure

被引：36

作者：

Fransen, Signe ^{[1
]}

Karmochkine, Marina ^{[2
]}

Huang, Wei ^{[1
]}

Weiss, Laurence ^{[2
,3
]}

Petropoulos, Christos J. ^{[1
]}

Charpentier, Charlotte ^{[3
,4
]}

机构：

[1] Monogram Biosci, San Francisco, CA USA

[2] Hop Europeen Georges Pompidou, AP HP, Serv Immunol Clin, Paris, France

[3] Univ Paris 05, Paris, France

[4] Hop Europeen Georges Pompidou, AP HP, Virol Lab, F-75015 Paris, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 10期

关键词：

RESISTANCE;

D O I：

10.1128/AAC.00651-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We characterized the raltegravir (RAL) susceptibility and the integrase (IN)-mediated replication capacity (RC) of RAL-resistant human immunodeficiency virus type 1 from two patients experiencing virologic failure during continuous RAL salvage therapy. The following two distinct outcomes were observed: (i) the selective outgrowth of virus with high-level RAL resistance and high IN-mediated RC leading to significant viral load rebound and (ii) the selection of virus with a slight reduction in RAL susceptibility and low IN-mediated RC resulting in sustained low-level viremia.

引用

页码：4522 / 4524

页数：3

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