Vitamin K and Osteoporosis

被引：88

作者：

Fusaro, Maria ^{[1
,2
]}

Cianciolo, Giuseppe ^{[3
]}

Brandi, Maria Luisa ^{[4
]}

Ferrari, Serge ^{[5
,6
]}

Nickolas, Thomas L. ^{[7
]}

Tripepi, Giovanni ^{[8
]}

Plebani, Mario ^{[9
]}

Zaninotto, Martina ^{[9
]}

Iervasi, Giorgio ^{[1
]}

La Manna, Gaetano ^{[3
]}

Gallieni, Maurizio ^{[10
]}

Vettor, Roberto ^{[2
]}

Aghi, Andrea ^{[11
]}

Gasperoni, Lorenzo ^{[3
]}

Giannini, Sandro ^{[11
]}

Sella, Stefania ^{[11
]}

M. Cheung, Angela ^{[12
]}

机构：

[1] Natl Res Council CNR, Inst Clin Physiol IFC, I-56124 Pisa, Italy

[2] Univ Padua, Dept Med, I-35128 Padua, Italy

[3] Univ Bologna, S Orsola Hosp, Dept Expt Diagnost & Specialty Med DIMES, Nephrol Dialysis & Renal Transplant Unit, I-40138 Bologna, Italy

[4] Univ Florence, Dept Biomed Expt & Clin Sci Mario Serio, I-50139 Florence, Italy

[5] Fac Med, Dept Med, Serv Bone Dis, CH-1205 Geneva, Switzerland

[6] Geneva Univ Hosp, CH-1205 Geneva, Switzerland

[7] Columbia Univ, Dept Med, Div Nephrol, New York, NY 10032 USA

[8] Osped Riuniti Reggio Calabria, Clin Epidemiol Renal Dis & Hypertens, CNR IFC, I-89124 Reggio Di Calabria, Italy

[9] Univ Padua, Dept Med, Lab Med Unit, I-35128 Padua, Italy

[10] Univ Milan, Dept Biomed & Clin Sci Luigi Sacco, I-20157 Milan, Italy

[11] Univ Padua, Dept Med, Clin Med 1, I-35128 Padua, Italy

[12] Univ Toronto, Univ Hlth Network, Dept Med, 200 Elizabeth St,Eaton North 7-221, Toronto, ON M5G 2C4, Canada

来源：

NUTRIENTS | 2020年 / 12卷 / 12期

关键词：

vitamin K; vitamin K-dependent proteins; Osteocalcin; matrix Gla protein; vitamin K levels; vitamin K deficiency; bone fractures; MATRIX GLA PROTEIN; GAMMA-CARBOXYGLUTAMIC ACID; POSTMENOPAUSAL WOMEN; FRACTURE INCIDENCE; HIP FRACTURE; BONE; OSTEOCALCIN; SUPPLEMENTATION; MENATETRENONE; RECEPTOR;

D O I：

10.3390/nu12123625

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Vitamin K acts as a coenzyme of carboxylase, catalyzing the carboxylation of several vitamin K dependent proteins. Beyond its well-known effects on blood coagulation, it also exerts relevant effects on bone and the vascular system. In this review, we point out the relevance of an adequate vitamin K intake to obtain sufficient levels of carboxylated (active form) vitamin K dependent proteins (such as Osteocalcin and matrix Gla protein) to prevent bone health. Another bone-related action of Vitamin K is being a ligand of the nuclear steroid and xenobiotic receptor (SXR). We also discuss the recommended intake, deficiency, and assessment of vitamin K. Furthermore, we review the few available studies that have as pre-specified outcome bone fractures, indicating that we need more clinical studies to confirm that vitamin K is a potential therapeutic agent for bone fractures.

引用

页码：1 / 13

页数：13

共 81 条

[41] Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women [J].