The aim of this studs was to evaluate the technical aspects and efficacy of placing tunneled central venous access catheters (CVA) in the inferior vena cava (IVC) via a direct translumbar approach. I Between August 1994 and July 1998, 50 CVA (Hickman 13.5 F) were placed in the IVC via a direct translumbar approach in 46 patients (10 males, 36 fe-males) with a mean age of 39.9 vears (age range 10-87 years). The indications were chemotherapy administration plus leukoaphoresis (n = 39), bone marrrow transplantation (n = 2) and hemodialysis (n = 5).;The reasons for placing the CVA in the IVC were cosmetic (n = 34), supradiaphragmatic venous thrombosis (n = 8). previous catheter infection (n = 2), and non-functioning arteriovenous fistula (n = 2). There were no immediate complications. The mean period of time the CVA was in place was 3 months (15 days to 15 months), during which the function was excellent. The commonest late complication was infection (4 local, 6 bacteremia). Others included: pain i (n = 2), ureteric fistula (n = I), pericatheter fibrin i sheath formation (n = 6) and catheter-tip impaction (n = 2). Two catheters were damaged due to postprocedural inappropriate manipulations and two others fell off due to incorrect fixation. Due to these complications, it was necessary to remove ten catheters, re-place an additional four and reposition two. Direct translumbar catheterization of the IVC is a safe and I effective way of placing a long-term CVA with a moderate complication rate.