Polyacrylonitrile-based carbon nanofibers as a matrix for laser desorption/ionization time-of-flight mass spectrometric analysis of small molecules under both positive and negative ionization modes

被引：12

作者：

Chae, Ari ^{[1
,2
]}

Lee, Gwanwon ^{[1
]}

Koh, Dong-Yeun ^{[2
]}

Yang, Cheol-Min ^{[1
]}

Lee, Sungho ^{[1
,3
]}

Kim, Young-Kwan ^{[4
]}

机构：

[1] Korea Inst Sci & Technol KIST, Inst Adv Composite Mat, Carbon Composite Mat Res Ctr, 92 Chudong Ro, Wanju Gun 55324, Jeollabuk Do, South Korea

[2] Korea Adv Inst Sci & Technol KAIST, Dept Chem & Biomol Engn, 2921 Daehak Ro, Daejeon 34141, South Korea

[3] Univ Sci & Technol, KIST Sch, Dept Nano Mat Engn, 217 Gajeong Ro, Daejeon 34113, South Korea

[4] Dongguk Univ Seoul, Dept Chem, 30 Pildong Ro, Seoul 04620, South Korea

来源：

ANALYTICAL AND BIOANALYTICAL CHEMISTRY | 2021年 / 413卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

Laser desorption; ionization; Mass spectrometry; Carbon nanofiber; Carbonization; Saccharide; DOPED GRAPHENE; NANOPARTICLES; DESORPTION; OXIDE; DOTS;

D O I：

10.1007/s00216-020-03083-9

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Carbon fiber (CNF), prepared by carbonization of electrospun polyacrylonitrile (PAN) fibers, is systematically investigated as a mediator to replace conventional organic matrices for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-MS). CNF exhibits a high salt tolerance, sensitivity, and resolution for organic matrix-free laser desorption/ionization time-of-flight mass spectrometry (LDI-MS) analysis of various analytes under both positive and negative ionization modes. Especially, saccharides, a neutral molecule having low negative ionization efficiency, are successfully detected with CNF. Taken together, this study clearly demonstrates CNF is a promising material to develop an efficient and universal platform for LDI-MS analysis regardless of preferential ionization modes of analytes.

引用

页码：1193 / 1202

页数：10

共 32 条

[1] A New Binary Matrix for Specific Detection of Mercury(II) Using Matrix-Assisted Laser Desorption Ionization Mass Spectrometry [J].