Electrical activity of artificial ion channels incorporated into planar lipid bilayers

被引：49
|
作者：
Voyer, N [1 ]
Potvin, L [1 ]
Rousseau, E [1 ]
机构：
[1] UNIV SHERBROOKE,DEPT PHYSIOL & BIOPHYS,SHERBROOKE,PQ J1K 2R1,CANADA
来源：
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 | 1997年 / 08期
关键词：
D O I：
10.1039/a701060e
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The ion transport ability in a planar lipid bilayer of a 21 amino acid peptide bearing six 21-crown-7 side chains is reported, The compound was designed to form an artificial ion channel by stacking the crown rings, when adopting an alpha-helical conformation in a bilayer membrane. All the derivatives of 1 exhibited membrane conductivity with the best results obtained with the unprotected analog 4, The latter showed typical single channel activity.
引用
收藏
页码：1469 / 1471
页数：3
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