Electrical activity of artificial ion channels incorporated into planar lipid bilayers

被引:49
|
作者
Voyer, N [1 ]
Potvin, L [1 ]
Rousseau, E [1 ]
机构
[1] UNIV SHERBROOKE,DEPT PHYSIOL & BIOPHYS,SHERBROOKE,PQ J1K 2R1,CANADA
来源
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 | 1997年 / 08期
关键词
D O I
10.1039/a701060e
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The ion transport ability in a planar lipid bilayer of a 21 amino acid peptide bearing six 21-crown-7 side chains is reported, The compound was designed to form an artificial ion channel by stacking the crown rings, when adopting an alpha-helical conformation in a bilayer membrane. All the derivatives of 1 exhibited membrane conductivity with the best results obtained with the unprotected analog 4, The latter showed typical single channel activity.
引用
收藏
页码:1469 / 1471
页数:3
相关论文
共 50 条
  • [1] Electrical activity of artificial ion channels incorporated into planar lipid bilayers
    Voyer, Normand
    Potvin, Lena
    Rousseau, Eric
    Royal Society of Chemistry
  • [2] Ion channels of Fasciola hepatica incorporated into planar lipid bilayers
    Jang, JH
    Kim, SD
    Park, JB
    Hong, SJ
    Ryu, PD
    PARASITOLOGY, 2004, 128 : 83 - 89
  • [3] Conformational and orientation studies of artificial ion channels incorporated into lipid bilayers
    Biron, E
    Voyer, N
    Meillon, JC
    Cormier, ME
    Auger, M
    BIOPOLYMERS, 2000, 55 (05) : 364 - 372
  • [4] SINGLE CALCIUM CHANNELS INCORPORATED INTO PLANAR LIPID BILAYERS
    NELSON, MT
    JOURNAL OF GENERAL PHYSIOLOGY, 1985, 86 (06): : A6 - A7
  • [5] ION CHANNELS IN ARTIFICIAL LIPID BILAYERS
    SANSOM, MSP
    MELLOR, IR
    NEUROTOX 88: MOLECULAR BASIS OF DRUG & PESTICIDE ACTION, 1988, 832 : 419 - 428
  • [6] Electrophysiological Properties of Ion Channels in Ascaris suum Tissue Incorporated into Planar Lipid Bilayers
    Park, Kwon Moo
    Kim, Sun-Don
    Park, Jin Bong
    Hong, Sung-Jong
    Ryu, Pan Dong
    KOREAN JOURNAL OF PARASITOLOGY, 2021, 59 (04): : 329 - 339
  • [7] RECONSTITUTION OF VACUOLAR ION CHANNELS INTO PLANAR LIPID BILAYERS
    KLUGHAMMER, B
    BENZ, R
    BETZ, M
    THUME, M
    DIETZ, KJ
    BIOCHIMICA ET BIOPHYSICA ACTA, 1992, 1104 (02) : 308 - 316
  • [8] DIFFERENT TYPES OF CARDIAC CALCIUM CHANNELS INCORPORATED INTO PLANAR LIPID BILAYERS
    WORLEY, JF
    FIEBER, LA
    JONES, L
    NELSON, MT
    BIOPHYSICAL JOURNAL, 1986, 49 (02) : A176 - A176
  • [9] CATION CHANNELS FROM TETRAHYMENA CILIA INCORPORATED INTO PLANAR LIPID BILAYERS
    OOSAWA, Y
    SOKABE, M
    AMERICAN JOURNAL OF PHYSIOLOGY, 1985, 249 (01): : C177 - C179
  • [10] ION CHANNELS FROM THE BACILLUS-SUBTILIS PLASMA-MEMBRANE INCORPORATED INTO PLANAR LIPID BILAYERS
    ALCAYAGA, C
    VENEGAS, R
    CARRASCO, A
    WOLFF, D
    FEBS LETTERS, 1992, 311 (03) : 246 - 250