Hypothalamic peroxisome proliferator-activated receptor gamma regulates ghrelin production and food intake

被引：9
作者：
Li, Qingjie [1 ]
Yu, Quan [2 ]
Lin, Li [1 ]
Zhang, Heng [1 ]
Peng, Miao [1 ]
Jing, Chunxia [3 ]
Xu, Geyang [1 ]
机构：
[1] Jinan Univ, Sch Med, Dept Physiol, 601 Huangpu Ave West, Guangzhou 510632, Guangdong, Peoples R China
[2] Jinan Univ, Sch Med, Cent Lab, Guangzhou, Guangdong, Peoples R China
[3] Jinan Univ, Sch Med, Dept Epidemiol, Guangzhou, Guangdong, Peoples R China
来源：
NEUROPEPTIDES | 2018年 / 69卷
基金：
中国国家自然科学基金;
关键词：
Peroxisome proliferator-activated receptor-gamma (PPAR gamma); Ghrelin; Mechanistic target of rapamycin complex 1 (mTORC1); Food intake; DES-ACYL GHRELIN; PPAR-GAMMA; ENERGY-BALANCE; GLUCOSE-METABOLISM; GROWTH-HORMONE; BODY-WEIGHT; PEPTIDE; HOMEOSTASIS; OBESITY; HUMANS;
D O I：
10.1016/j.npep.2018.04.002
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Peroxisome proliferator-activated receptor-gamma (PPAR gamma) regulates fatty acid storage, glucose metabolism, and food intake. Ghrelin, a gastric hormone, provides a hunger signal to the central nervous system to stimulate appetite. However, the effects of PPAR gamma on ghrelin production are still unclear. In the present study, the effects of PPAR gamma on ghrelin production were examined in lean- or high-fat diet-induced obese (DIO) C57BL/6J mice and mHypoE-42 cells, a hypothalamic cell line. 3rd intracerebroventricular injection of adenoviral-directed overexpression of PPAR gamma (Ad-PPAR gamma) reduced hypothalamic and plasma ghrelin, food intake in both lean C57BL/6J mice and diet induced obese mice. These changes were associated with a significant increase in mechanistic target of rapamycin complex 1 (mTORC1) activity. Overexpression of PPAR gamma enhanced mTORC1 signaling and suppressed ghrelin production in cultured mHypoE-42 cells. Our results suggest that hypothalamic PPAR gamma plays a vital role in ghrelin production and food intake in mice.
引用
收藏
页码：39 / 45
页数：7
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