Copper-catalyzed cycloaddition between hydrogen phosphonates and activated alkenes: synthesis of phosphonoisoquinolinediones

被引：43
作者：
Wu, Ju [1 ]
Gao, Yuzhen [1 ]
Zhao, Xin [1 ]
Zhang, Liangliang [1 ]
Chen, Weizhu [1 ,2 ]
Tang, Guo [1 ]
Zhao, Yufen [1 ]
机构：
[1] Xiamen Univ, Coll Chem & Chem Engn, Key Lab Chem Biol Fujian Prov, Dept Chem, Xiamen 361005, Fujian, Peoples R China
[2] State Ocean Adm, Inst Oceanog 3, Xiamen 361005, Fujian, Peoples R China
来源：
RSC ADVANCES | 2016年 / 6卷 / 01期
关键词：
BIOLOGICAL EVALUATION; DEAROMATIZATION ACCESS; ACIDS SYNTHESIS; H-PHOSPHONATES; TRIFLUOROMETHYLATION; CYCLIZATION; OXYPHOSPHORYLATION; FUNCTIONALIZATION; LACTONIZATION; INHIBITORS;
D O I：
10.1039/c5ra22570a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new, general method for the synthesis of phosphonoisoquinolinediones has been achieved via copper-catalyzed phosphonation-cyclization of various methacryloylbenzamides with P(O)H compounds. This transformation allows the direct formation of a P-C bond and the construction of an isoquinolinedione ring in one reaction.
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收藏
页码：303 / 306
页数：4
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