A new biodegradable crosslinked polyethylene oxide sulfide (PEOS) hydrogel for controlled drug release

被引：43

作者：

Koo, Heebeom ^{[1
]}

Jin, Geun-woo ^{[1
]}

Kang, Hyunseo ^{[1
]}

Lee, Yan ^{[2
]}

Nam, Hye Yeong ^{[1
]}

Jang, Hyung-suk ^{[3
]}

Park, Jong-Sang ^{[1
]}

机构：

[1] Seoul Natl Univ, Sch Chem & Mol Engn, Seoul 151742, South Korea

[2] Univ Tokyo, Grad Sch Med, Ctr Dis Biol & Integrat Med, Div Clin Biotechnol,Bunkyo Ku, Tokyo 1138656, Japan

[3] Sungkyunkwan Univ, Sch Med, Samsung Biomed Res Inst, Cardiac & Vasc Ctr,Dept Med,Samsung Med Ctr, Seoul 135710, South Korea

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2009年 / 374卷 / 1-2期

关键词：

Hydrogel; PEG; Disulfide; Biodegradable; DDS; TRIBLOCK COPOLYMERS; ORAL TOLERANCE; GENE DELIVERY; IN-VITRO; POLY(ETHYLENE; NANOPARTICLES; DISULFIDE; PEG; TEMPERATURE; INDUCTION;

D O I：

10.1016/j.ijpharm.2009.03.010

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We developed a polyethylene glycol (PEG)-based biodegradable hydrogel through disulfide crosslinking of polyethylene oxide sulfide (PEOS). The crosslinking rate was highly dependent on temperature, and incubation at about 40-50 degrees C was required for efficient crosslinking. The crosslinked PEOS hydrogel showed glutathione-dependent dissolution and corresponding controlled release of a model drug-fluorescein isothiocyanate (FITC)-labeled dextran-because the disulfide bond, the main linker, is selectively degraded in response to the high concentration of glutathione. The temperature-sensitive crosslinking and the hydrogel formation have the potential for use as an injectable biogel precursor, which was confirmed by in situ gel formation in mice. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：58 / 65

页数：8

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