Methyl protodioscin induces G2/M cell cycle arrest and apoptosis. in HepG2 liver cancer cells

被引：83
|
作者：
Wang, Guanghui
Chen, Haifeng
Huang, Minghui
Wang, Naili
Zhang, Jinchao
Zhang, Yaou
Bai, Ganrong
Fong, Wang-Fun
Yang, Mengsu
Yao, Xinsheng
机构：
[1] City Univ Hong Kong, Dept Biochem & Chem, Kowloon, Hong Kong, Peoples R China
[2] City Univ Hong Kong, Shenzhen Biotech & Hlth Ctr, Shenzhen Inst, Kowloon 518057, Hong Kong, Peoples R China
[3] Shenyang Pharmaceut Univ, Dept Nat Prod Chem, Shenyang 110016, Peoples R China
[4] Tsing Hua Univ, Grad Sch, Shenzhen 518055, Peoples R China
[5] Univ Town, Shenzhen Res Ctr Tradit Chinese Med & Nat Prod, Shenzhen 518055, Peoples R China
来源：
CANCER LETTERS | 2006年 / 241卷 / 01期
关键词：
methyl protodioscin; G(2)/M arrest; apoptosis;
D O I：
10.1016/j.canlet.2005.10.050
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Methyl protodioscin (NSC-698790) is one of the main bioactive components in the traditional Chinese medicine Dioscorea collettii var. hypoglauca (Dioscoreaceae). In this study, we investigated the anti-proliferative effect of methyl protodioscin on the HepG2 cells and the mechanism of the induced cytotoxicity. Treatment of methyl protodioscin resulted in G2/M arrest and apoptosis in HepG2 cells. These effects were attributed to down-regulation of Cyclin 131 and the signaling pathways leading to up-regulation of Bax and down-regulation of BCL2, suggesting that methyl protodioscin may be a novel anti-mitotic agent. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：102 / 109
页数：8
相关论文
共 50 条
  • [1] A resveratrol analog, phoyunbene B, induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells
    Wang, Guanghui
    Guo, Xiaoyu
    Chen, Haifeng
    Lin, Ting
    Xu, Yang
    Chen, Quancheng
    Liu, Jie
    Zeng, Jinzhang
    Zhang, Xiao-kun
    Yao, Xinsheng
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (05) : 2114 - 2118
  • [2] Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in A549 human lung cancer cells
    Bai, Yang
    Qu, Xiao-Yuan
    Yin, Jun-Qiang
    Wu, Liangcai
    Jiang, Hong
    Long, Han-Wu
    Jia, Qiang
    PHARMACOGNOSY MAGAZINE, 2014, 10 (39) : 318 - 324
  • [3] Osthole induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells
    Chao, Xu
    Zhou, Xiaojun
    Zheng, Gang
    Dong, Changhu
    Zhang, Wei
    Song, Xiaomei
    Jin, Tianbo
    PHARMACEUTICAL BIOLOGY, 2014, 52 (05) : 544 - 550
  • [4] Induction of Apoptosis and G2/M Cell Cycle Arrest by Myricetin in Human Hepatoma HepG2 Cells
    Zhang Xiu-juan
    Huang Qing-ling
    Ji Yu-bin
    2009 IEEE INTERNATIONAL SYMPOSIUM ON IT IN MEDICINE & EDUCATION, VOLS 1 AND 2, PROCEEDINGS, 2009, : 1104 - 1107
  • [5] NCPMF-60 induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells
    Dai, Qin-Sheng
    Liu, Wei
    Wang, Xiao-Bing
    Lu, Na
    Gong, Dan-Dan
    Kong, Ling-Yi
    Guo, Qing-Long
    ANTI-CANCER DRUGS, 2011, 22 (01) : 46 - 57
  • [6] Methyl protodioscin induces G2/M arrest and apoptosis in K562 cells with the hyperpolarization of mitochondria
    Liu, MJ
    Yue, PYK
    Wang, Z
    Wong, RNS
    CANCER LETTERS, 2005, 224 (02) : 229 - 241
  • [7] Asparanin A induces G2/Mcell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells
    Liu, Wei
    Huang, Xue-Feng
    Qi, Qi
    Dai, Qin-Sheng
    Yang, Li
    Nie, Fei-Fei
    Lu, Na
    Gong, Dan-Dan
    Kong, Ling-Yi
    Guo, Qing-Long
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009, 381 (04) : 700 - 705
  • [8] Oridonin induces G2/M cell cycle arrest and apoptosis through MAPK and p53 signaling pathways in HepG2 cells
    Wang, Hui
    Ye, Yan
    Chu, Jian-Hong
    Zhu, Guo-Yuan
    Li, Ying-Wei
    Fong, David W. F.
    Yu, Zhi-Ling
    ONCOLOGY REPORTS, 2010, 24 (03) : 647 - 651
  • [9] Deoxypodophyllotoxin induces G2/M cell cycle arrest and apoptosis in HeLa cells
    Shin, Soon Young
    Yong, Yeonjoong
    Kim, Chang Gun
    Lee, Young Han
    Lim, Yoongho
    CANCER LETTERS, 2010, 287 (02) : 231 - 239
  • [10] Knockout of PRDX6 induces mitochondrial dysfunction and cell cycle arrest at G2/M in HepG2 hepatocarcinoma cells
    Lopez-Grueso, Maria Jose
    Jose Lagal, Daniel
    Garcia-Jimenez, Alvaro Fernando
    Maria Tarradas, Rosa
    Carmona-Hidalgo, Beatriz
    Peinado, Jose
    Requejo-Aguilar, Raquel
    Antonio Barcena, Jose
    Alicia Padilla, Carmen
    REDOX BIOLOGY, 2020, 37
12345