Monitoring chlorinated persistent organic pollutants in adolescents in Flanders (Belgium): Concentrations, trends and dose-effect relationships (FLEHS II)

被引:32
作者
Croes, Kim [1 ]
Den Hond, Elly [2 ]
Bruckers, Liesbeth [3 ]
Loots, Ilse [4 ]
Morrens, Bert [4 ]
Nelen, Vera [5 ]
Colles, Ann [2 ]
Schoeters, Greet [2 ]
Sioen, Isabelle [6 ]
Covaci, Adrian [7 ]
Vandermarken, Tara [1 ]
Van Larebeke, Nicolas [1 ]
Baeyens, Willy [1 ]
机构
[1] Vrije Univ Brussel, Dept Analyt Environm & Geochem AMGC, Brussels, Belgium
[2] Vlaamse Instelling Technol Onderzoek, Environm Hlth & Risk, B-2400 Mol, Belgium
[3] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Hasselt, Belgium
[4] Univ Antwerp, B-2020 Antwerp, Belgium
[5] Prov Inst Hyg, Antwerp, Belgium
[6] Univ Ghent, Dept Publ Hlth, B-9000 Ghent, Belgium
[7] Univ Antwerp, Toxicol Ctr, B-2020 Antwerp, Belgium
基金
比利时弗兰德研究基金会;
关键词
Chlorinated POPs; FLEHS II; Dose-effect; Hormones; Human biomonitoring; Sexual development; THYROID-HORMONE LEVELS; POLYBROMINATED DIPHENYL ETHERS; HUMAN BIOMONITORING PROGRAM; DIOXIN-LIKE PCBS; POLYCHLORINATED-BIPHENYLS; HUMAN SERUM; ORGANOCHLORINE POLLUTANTS; HUMAN-MILK; ENVIRONMENTAL EXPOSURE; REPRODUCTIVE FUNCTION;
D O I
10.1016/j.envint.2014.05.022
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Background: In 2007, the second cycle of the Flemish human biomonitoring survey started, with a main focus on 14-15 year-old adolescents. Objectives: The main objectives were generating reference values for exposure markers, determining the pollution pressure in industrial hotspots and establishing dose-effect relationships between exposure to pollutants and hormone levels, sexual development, asthma and allergy, genotoxic and hematological markers. Methods: Geometric means with 95% confidence intervals (CI) were calculated for a reference population of 200 14-15 year-old adolescents. Stepwise multiple regression analyses with correction for confounders and covariates were performed to establish dose-effect relationships. Results: Geometric mean concentrations (with 95% Cl) of 49.6 (45.7, 53.8), 70.8 (63.6, 78.8) and 8.34 (7.76, 8.97) ng g(-1) lipid for the sum of PCB 138, 153 and 180, p,p'-DDE and HCB were respectively 23%, 26% and 60% lower than those obtained five years earlier. Geometric mean concentrations of 108 (101, 114) and 32.1 (30.1, 34.2) pg CALUX-BEQ g(-1) lipid were observed for the PCDD/Fs and dioxin-like PCBs, respectively. Multiple dose-effect relationships were observed between POPs and several effect markers, including positive (boys) and negative (girls) associations with data on sexual development and positive associations with asthma, animal allergy and free thyroxine (boys and girls). Conclusions: Our findings suggest that chlorinated POP concentrations are decreasing over time and that even relatively low concentrations are associated with biological effects. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码:20 / 28
页数:9
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