Using chitosan nanoparticles as drug carriers for the development of a silver sulfadiazine wound dressing

被引:60
作者
El-Feky, Gina S. [1 ,2 ]
Sharaf, Samar S. [3 ]
El Shafei, Amira [3 ]
Hegazy, Aisha A. [3 ]
机构
[1] Natl Res Ctr, Dept Pharmaceut Technol, Cairo, Egypt
[2] October Univ Modern Sci & Arts, Fac Pharm, 6Th Of October City, Egypt
[3] Natl Res Ctr, Text Res Div, Cairo, Egypt
关键词
Silver sulfadiazine; Chitosan nanoparticles; Wound dressing; CHITOSAN/CYCLODEXTRIN NANOPARTICLES; BIOMEDICAL APPLICATIONS; CLINICAL-EVALUATION; DELIVERY SYSTEM; RECOVERY STAGE; CROSS-LINKING; ANTIBACTERIAL; GEL; POLYSACCHARIDES; BEDSORE;
D O I
10.1016/j.carbpol.2016.11.054
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
Burn wounds environment favors the growth of micro-organisms causing delay in wound healing. The traditional treatment with antimicrobial creams offer inaccurate doses. In the present study, a dressing coated with silver sulfadiazine (SSD) loaded chitosan nanoparticles (CSNPs) for the controlled-release of SSD into burn wound to control bacterial growth was investigated. CSNPs were formulated with different concentrations of chitosan and CM-beta-CD and loaded with SSD complexed in 1:1 molar ratio with CM-beta-CD,CSNPs were assessed for their particle size, polydispersity index, morphology and association efficiency. The formula showing the best characteristics was selected for the preparation of SSD loaded CSNPs wound dressing through a padding process with/without the use of cross-linker. The dressing was characterized for its physical properties, in addition, FTIR, X-ray, SEM and in vitro release were used for characterization. The dressing was proven effective for the inhibition of the growth of Gram positive and Gram negative bacteria as well as candida on an infected wound. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码:11 / 19
页数:9
相关论文
共 38 条
[1]  
Adhya Abhishek, 2014, J Basic Clin Pharm, V6, P29, DOI 10.4103/0976-0105.145776
[2]   Arginine-assisted immobilization of silver nanoparticles on ZnO nanorods: an enhanced and reusable antibacterial substrate without human cell cytotoxicity [J].
Agnihotri, Shekhar ;
Bajaj, Geetika ;
Mukherji, Suparna ;
Mukherji, Soumyo .
NANOSCALE, 2015, 7 (16) :7415-7429
[3]   Physical, antibacterial and antioxidant properties of chitosan films incorporated with thyme oil for potential wound healing applications [J].
Altiok, Duygu ;
Altiok, Evren ;
Tihminlioglu, Funda .
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2010, 21 (07) :2227-2236
[4]   Chitosan/cyclodextrin nanoparticles as drug delivery system [J].
Ammar, Hussein Osman ;
El-Nahhas, S. A. ;
Ghorab, M. M. ;
Salama, A. H. .
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, 2012, 72 (1-2) :127-136
[5]   Chitin, Chitosan, and Its Derivatives for Wound Healing: Old and New Materials [J].
Azuma, Kazuo ;
Izumi, Ryotaro ;
Osaki, Tomohiro ;
Ifuku, Shinsuke ;
Morimoto, Minoru ;
Saimoto, Hiroyuki ;
Minami, Saburo ;
Okamoto, Yoshiharu .
JOURNAL OF FUNCTIONAL BIOMATERIALS, 2015, 6 (01) :104-142
[6]   Structure and interactions in chitosan hydrogels formed by complexation or aggregation for biomedical applications [J].
Berger, J ;
Reist, M ;
Mayer, JM ;
Felt, O ;
Gurny, R .
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2004, 57 (01) :35-52
[7]   Wound healing dressings and drug delivery systems: A review [J].
Boateng, Joshua S. ;
Matthews, Kerr H. ;
Stevens, Howard N. E. ;
Eccleston, Gillian M. .
JOURNAL OF PHARMACEUTICAL SCIENCES, 2008, 97 (08) :2892-2923
[8]  
Calvo P, 1997, J APPL POLYM SCI, V63, P125, DOI 10.1002/(SICI)1097-4628(19970103)63:1<125::AID-APP13>3.0.CO
[9]  
2-4
[10]   Development of chitosan oleate ionic micelles loaded with silver sulfadiazine to be associated with platelet lysate for application in wound healing [J].
Dellera, Eleonora ;
Bonferoni, Maria Cristina ;
Sandri, Giuseppina ;
Rossi, Silvia ;
Ferrari, Franca ;
Del Fante, Claudia ;
Perotti, Cesare ;
Grisoli, Pietro ;
Caramella, Carla .
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2014, 88 (03) :643-650