Cessation of HIV-1 Transcription by Inhibiting Regulatory Protein Rev-Mediated RNA Transport

被引：15

作者：

Cao, Yuan ^{[1
]}

Liu, Xinyong ^{[1
]}

De Clercq, Erik ^{[2
]}

机构：

[1] Shandong Univ, Inst Med Chem, Sch Pharmaceut Sci, Jinan 250012, Peoples R China

[2] Katholieke Univ Leuven, Rega Inst Med Res, Louvain, Belgium

来源：

CURRENT HIV RESEARCH | 2009年 / 7卷 / 01期

基金：

中国国家自然科学基金; 高等学校博士学科点专项科研基金;

关键词：

AIDS; HIV-1; transcription; inhibitors; Rev; RRE; antiviral; IMMUNODEFICIENCY-VIRUS TYPE-1; ARGININE-RICH MOTIF; NUCLEAR EXPORT; MESSENGER-RNA; RESPONSE ELEMENT; GENE-EXPRESSION; LEPTOMYCIN B; CELLULAR COFACTOR; SMALL MOLECULES; UNSPLICED RNA;

D O I：

10.2174/157016209787048564

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The HIV-1 Rev protein, which traffics through nucleolus and shuttles between nucleus and cytoplasm, facilitates export of unspliced and singly spliced viral transcripts containing RRE RNA by the CRM1 export pathway. Inhibitions of the various stages of Rev-mediated RNA transport can arrest HIV-1 transcriptional process. The current understanding to the mechanism of Rev function, Rev-RRE interaction, as well as inhibitors hereof is reviewed.

引用

页码：101 / 108

页数：8

共 60 条

[11] Proflavine acts as a Rev inhibitor by targeting the high-affinity Rev binding site of the Rev responsive element of HIV-1 [J].

DeJong, ES ;

Chang, CE ;

Gilson, MK ;

Marino, JP .

BIOCHEMISTRY, 2003, 42 (26) :8035-8046

[12] FUNCTION OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 AND TYPE-2 REV PROTEINS IS DEPENDENT ON THEIR ABILITY TO INTERACT WITH A STRUCTURED REGION PRESENT IN ENV GENE MESSENGER-RNA [J].

DILLON, PJ ;

NELBOCK, P ;

PERKINS, A ;

ROSEN, CA .

JOURNAL OF VIROLOGY, 1990, 64 (09) :4428-4437

[13] Effect of Rev on the intranuclear localization of HIV-1 unspliced RNA [J].

Favaro, JP ;

Borg, KT ;

Arrigo, SJ ;

Schmidt, MG .

VIROLOGY, 1998, 249 (02) :286-296

[14] Rev-mediated nuclear export of RNA is dominant over nuclear retention and is coupled to the Ran-GTPase cycle [J].

Fischer, U ;

Pollard, VW ;

Lührmann, R ;

Teufel, M ;

Michael, MW ;

Dreyfuss, G ;

Malim, MH .

NUCLEIC ACIDS RESEARCH, 1999, 27 (21) :4128-4134

[15] Nucleocytoplasmic transport: taking an inventory [J].

Fried, H ;

Kutay, U .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2003, 60 (08) :1659-1688

[16] Development of a functional backbone cyclic mimetic of the HTV-1 Tat arginine-rich motif [J].

Friedler, A ;

Friedler, D ;

Luedtke, NW ;

Tor, Y ;

Loyter, A ;

Gilon, C .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (31) :23783-23789

[17] Peptide-triggered conformational switch in HIV-1 RRE RNA complexes [J].

Gosser, Y ;

Hermann, T ;

Majumdar, A ;

Hu, WD ;

Frederick, R ;

Jiang, F ;

Xu, WJ ;

Patel, DJ .

NATURE STRUCTURAL BIOLOGY, 2001, 8 (02) :146-150

[18] Selection and characterization of human immunodeficiency virus type 1 mutants that are resistant to inhibition by the transdominant negative RevM10 protein [J].

Hamm, TE ;

Rekosh, D ;

Hammarskjöld, ML .

JOURNAL OF VIROLOGY, 1999, 73 (07) :5741-5747

[19]

Hamy F, 2001, J BIOMOL SCREEN, V6, P179, DOI 10.1089/108705701300362719

[20] Effects of 1,8-diaminooctane on the FIV Rev regulatory system [J].

Hart, RA ;

Billaud, JN ;

Choi, SJ ;

Phillips, TR .

VIROLOGY, 2002, 304 (01) :97-104

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