A new biomarker for closed-loop deep brain stimulation in the subthalamic nucleus for patients with Parkinson's disease

被引:0
作者
Gmel, Gerrit E. [1 ,2 ,3 ]
Parker, John L. [1 ,2 ,3 ]
Hamilton, Tara J. [2 ,3 ,4 ]
机构
[1] Natl Informat & Commun Technol, Implant Syst Grp, Eveleigh, NSW 2015, Australia
[2] Univ New S Wales, Sch Elect Engn & Telecommun, Sydney, NSW 2052, Australia
[3] Univ New S Wales, Grad Sch Biomed Engn, Sydney, NSW 2052, Australia
[4] Univ Western Sydney, MARCS Inst, Penrith, NSW 2751, Australia
来源
2014 IEEE BIOMEDICAL CIRCUITS AND SYSTEMS CONFERENCE (BIOCAS) | 2014年
关键词
deep brain stimulation; feedback; Parkinson's disease; subthalamic nucleus; biomarker; basal ganglia;
D O I
暂无
中图分类号
TP [自动化技术、计算机技术];
学科分类号
0812 ;
摘要
Deep brain stimulation (DBS) has become the standard treatment for advanced stages of Parkinson's disease and other motor disorders. Although the surgical procedure has gained in accuracy over the years thanks to imaging and microelectrode recordings, the underlying principles of DBS are still debated today. The lack of a clear measurable biomarker for the efficacy of the therapy has rendered efforts to design feedbackenabled stimulators difficult. Our most recent intraoperative recordings have unveiled a new biomarker based on stimulation induced evoked responses that could lead to a new approach to closing the loop and designing an adaptive deep brain stimulator.
引用
收藏
页码:500 / 503
页数:4
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