Lack of evidence of association between IFNG and IL28B polymorphisms and QuantiFERON-CMV test results in seropositive transplant patients

被引：4

作者：

Aguado, Rocio ^{[1
]}

Paez-Vega, Aurora ^{[1
]}

Aguera, Maria L. ^{[1
,2
]}

Montejo, Miguel ^{[3
]}

Guirado, Lluis ^{[4
]}

Fortun, Jesus ^{[5
]}

Suarez-Benjumea, Alejandro ^{[6
]}

Len, Oscar ^{[7
]}

Farinas, Maria C. ^{[8
]}

de Gracia, Carmen ^{[9
]}

Hernandez, Domingo ^{[10
]}

Cobos-Ceballos, Maria J. ^{[11
]}

Torre-Cisneros, Julian ^{[1
,12
]}

Cantisan, Sara ^{[1
]}

机构：

[1] Univ Cordoba, Reina Sofia Univ Hosp, Inst Maimonides Invest Biomed Cordoba IMIBIC, REIPI RD12 0015 & REIPI RD16 0016 0008, Cordoba, Spain

[2] Reina Sofia Hosp, Dept Nephrol, REDinREN RD16 0009 0034, Cordoba, Spain

[3] Cruces Hosp, Infect Dis Unit, Bilbao, Spain

[4] Puigvert Fundacio, REDinREN RD16 0009 0019, Dept Nephrol, Barcelona, Spain

[5] Raman y Cajal Hosp, Infect Dis Unit, REIPI RD16 0016 0011, Madrid, Spain

[6] Virgen Rocio Univ Hosp, Dept Nephrol, Seville, Spain

[7] Hosp Univ Vall dHebron, REIPI RD16 0016 0003, Infect Dis Unit, Barcelona, Spain

[8] Univ Cantabria, Infect Dis Unit, Marques Valdecilla Hosp, IDIVAL,REIPI RD16 0016 0007, Santander, Spain

[9] Virgen Nieves Hosp, Dept Nephrol, Granada, Spain

[10] Univ Malaga, Carlos Haya Reg Univ Hosp, Dept Nephrol, IBIMA,REDinREN RD16 0009 0006, Malaga, Spain

[11] Reina Sofia Hosp, Dept Pneumol, Cordoba, Spain

[12] Reina Sofia Hosp, Infect Dis Unit, Cordoba, Spain

来源：

HUMAN IMMUNOLOGY | 2018年 / 79卷 / 06期

关键词：

Genetic polymorphisms; Cytokines; Solid organ transplantation; Cytomegalovirus infection; QuantiFERON-CMV; CELL-MEDIATED-IMMUNITY; ORGAN TRANSPLANT; CYTOMEGALOVIRUS-INFECTION; GENE POLYMORPHISM; HEPATITIS-C; GAMMA GENE; RECIPIENTS; RISK; RESPONSES; DISEASE;

D O I：

10.1016/j.humimm.2018.03.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The aim of this study was to analyze the relationship between the IFNG + 874 T/A and IL28B (rs12979860) C/T polymorphisms and the secretion of IFNG by CD8 + T cells after stimulation with cytomegalovirus (CMV) peptides, measured using QuantiFERON-CMV (QF-CMV) assay. A total of 184 CMV-seropositive solid organ transplant patients (108 kidney, 68 liver and 8 lung) were recruited. Of them, 151 patients were QF-CMV Reactive (IFNG >= 0.2 UI/mL) and 33 were Non-reactive. Genotype frequencies in the study population were TT (26.6%), AT (50.0%) and AA (23.4%) for IFNG +874 and CC (52.7%), CT (39.1%) and TT (8.2%) for 1128B (rs12979860). These frequencies did not significantly differ between QF-CMV Reactive and Non-reactive patients. Nor were any significant differences observed in the quantitative IFNG level among the genotypes in either the IFNG or the 1128 genes. When we analyzed whether these polymorphisms had any impact on the risk of CMV replication after transplantation, the adjusted analysis showed no association. In summary, our results showed that IFNG + 874 T/A and 1128B (rs12979860) C/T polymorphisms are not associated with the IFNG response to CMV measured by the QuantiFERON-CMV assay, although these results should be confirmed with a higher number of patients.

引用

页码：499 / 505

页数：7

共 30 条

[1] Pretransplant Immediately Early-1-Specific T Cell Responses Provide Protection for CMV Infection After Kidney Transplantation [J].