Changes in the pre-transplant bone-mineral metabolism do not affect the initial progress of the renal graft

Background. abnormalities in serum calcium, phosphate, and Parathyroid Hormone (HPT) concentrations are common in patients with chronic kidney disease and have been associated with increased morbidity and mortality. One of the most common problems in the first weeks after renal transplantation is Delayed Graft Function (DGF). There are several well-known risk factors for DGF development, but the role of calcium-phosphate-HPT homeostasis as a risk factor for early graft dysfunction is controversial. This issue was addressed in the current study. Methods: Pretransplant HPT, calcium and phosphate values were gathered in 449 patients that received a renal transplant in our center between 1994 and 2007. Other variables expected to influence the risk for delayed graft function were included from the clinical charts. Results: The incidence of DGF was 27.3%. DGF development was significantly associated with recipient age, type and need of renal replacement therapy, peak panel reactive antibodies, transfusion number and donor age. There were no significant differences in the mean pretransplant values of calcium (9.4 +/- 1.0 vs. 9.5 +/- 0.9 mg/dl, p = 0.667), phosphate (5.7 +/- 1.8 vs. 5.5 +/- 1.5 mg/dl, p = 0.457), calcium-phosphate product (53.5 +/- 17.2 vs. 51.8 +/- 14.6 mg(2)/dl(2), p = 0.413) and HPT (315 +/- 312 vs. 340 +/- 350 pg/ml, p = 0.530) between patients with and without DGF Conclusions: In our study population pretransplant serum HPT calcium and phosphorus levels have no influence on the risk for DGF