Genetic polymorphisms of IL-18 rs1946518 and IL-1β rs16944 are associated with prognosis and survival of acute myeloid leukemia

被引：35
作者：
Wang, Hong [1 ,2 ]
Hua, Mingqiang [1 ]
Wang, Shukang [3 ]
Yu, Jie [1 ]
Chen, Chen [1 ]
Zhao, Xueyun [1 ]
Zhang, Chen [1 ]
Zhong, Chaoqin [1 ]
Wang, Ruiqing [1 ]
He, Na [1 ]
Hou, Ming [1 ]
Ma, Daoxin [1 ]
机构：
[1] Shandong Univ, Qilu Hosp, Dept Hematol, 107 West Wenhua Rd, Jinan 250012, Peoples R China
[2] Zibo Cent Hosp, Dept Hematol, Zibo, Shandong, Peoples R China
[3] Shandong Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Jinan, Peoples R China
来源：
INFLAMMATION RESEARCH | 2017年 / 66卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Acute myeloid leukemia; Polymorphism; Inflammasome; NLRP3; Susceptibility; NF-KAPPA-B; INSERTION/DELETION POLYMORPHISM; PROMOTER POLYMORPHISMS; RISK; SUSCEPTIBILITY; CANCER; NFKB1; INTERLEUKIN-18; CARCINOMA; ACTIVATION;
D O I：
10.1007/s00011-016-1012-4
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Though the pathogenesis of AML is still unknown, accumulating evidence revealed that immune response plays a vital part in it. NLRP3 inflammasome as a component of immune system has been found related to several cancers. The single nucleotide polymorphisms (SNPs) of NLRP3 inflammasome genes may be related to pathogenesis and prognosis of AML. We determined polymorphisms of NLRP3 (rs35829419), CARD8 (rs2043211), IL-1 beta (rs16944), IL-18 (rs1946518) and NF-kappa B -94 ins/del ATTG in de novo AML patients to find out whether they play roles in the susceptibility and severity of AML. In our study, 383 AML cases and 300 randomly selected healthy individuals were examined for the polymorphisms and expression of NLRP3 genes. IL-1 beta (rs16944) polymorphism in different risk AML subgroups was found statistically different, with more GA genotype in favorable-risk cytogenetics group. We also demonstrated that the bone marrow blasts of patients carrying IL-18 (rs1946518) GG or GT genotype were higher than patients of TT genotype. IL-18 plasma level of patients with IL-18 (rs1946518) GT or TT genotype was higher than GG genotype. Moreover, the GT genotype of IL-18 (rs1946518) led to statistically poorer AML-specific survival. IL-1 beta (rs16944) and IL-18 (rs1946518) may be served as potential predictors for AML.
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收藏
页码：249 / 258
页数：10
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