A versatile asymmetric synthesis of highly enantiomerically enriched 12(S)-HETE via a combination of enzymatic and chemical processes

被引：10

作者：

Suh, YG

Min, KH

Lee, YS

Seo, SY

Kim, SH

Park, HJ

机构：

[1] Seoul Natl Univ, Coll Pharm, Kwanak Gu, Seoul 151742, South Korea

[2] Sungkyunkwan Univ, Coll Pharm, Suwon 440746, South Korea

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 21期

关键词：

D O I：

10.1016/S0040-4039(02)00670-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This paper describes a versatile asymmetric synthesis of highly enantiomerically enriched 12(S)-HETE via enzymatic kinetic resolution of the key allylic alcohol synthon and the facile introduction of three alkyne units which were concomitantly converted to three alkenes units. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：3825 / 3828

页数：4

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