Thoughts on mammalian prion strains

被引：0

作者：

Weissmann, Charles ^{[1
]}

机构：

[1] Scripps Florida, Dept Infectol, Jupiter, FL 33458 USA

来源：

FOLIA NEUROPATHOLOGICA | 2009年 / 47卷 / 02期

关键词：

CDI; conformation-dependent immunoassay; conformation templating; conformational population distribution; conversion; PrPc-to-PrP5c; CPA; cell panel assay; Gajdusek; glycoform; PMCA; protein misfolding cyclic amplification; protein-only; SSCA; standard scrapie cell assay; strains; TSE; transmissible spongiform encephalopathy; BOVINE SPONGIFORM ENCEPHALOPATHY; MISFOLDING CYCLIC AMPLIFICATION; CHRONIC WASTING DISEASE; SCRAPIE INFECTION; TRANSGENIC MICE; MOUSE SCRAPIE; CELL-CULTURE; PROTEIN; RESISTANT; PRP;

D O I：

暂无

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A plethora of prion strains can be propagated indefinitely in hosts homozygous for the PrP gene. Within the framework of the "protein-only" hypothesis, the strain-specific properties are enciphered in the conformation of the strain-associated PrP5c. Are these conformations codetermined by additional components, whose presence or absence within an infected cell could define the cell's competence to replicate a particular strain? Which cellular components, if any, contribute to the PrPc-to-PrP5c conversion in the cell? Many questions still remain to be answered in the field launched and nurtured by Carlton Gajdusek, to whom this essay is dedicated.

引用

页码：104 / 113

页数：10

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