Neuroprotective and neurorestorative strategies for Parkinson's disease

被引：142
作者：
Dawson, TM
Dawson, VL [1 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Inst Cell Engn, Baltimore, MD 21287 USA
[2] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21287 USA
[3] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21287 USA
[4] Johns Hopkins Univ, Sch Med, Dept Physiol, Baltimore, MD 21287 USA
来源：
NATURE NEUROSCIENCE | 2002年 / 5卷 / Suppl 11期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nn941
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Advances in understanding the molecular mechanisms of cell death and the pathogenesis of sporadic and familial Parkinson's disease are creating new opportunities for the development of neuroprotective and/or neurorestorative therapies. Here we review many of these advances, highlighting areas and strategies that might be particularly suited to the development of innovative approaches that prevent degeneration and/or restore function in Parkinson's disease.
引用
收藏
页码：1058 / 1061
页数：4
相关论文
共 35 条
[1]   Chaperone suppression of α-synuclein toxicity in a Drosophila model for Parkinson's disease [J].
Auluck, PK ;
Chan, HYE ;
Trojanowski, JQ ;
Lee, VMY ;
Bonini, NM .
SCIENCE, 2002, 295 (5556) :865-868
[2]   Experimental models of Parkinson's disease [J].
Beal, MF .
NATURE REVIEWS NEUROSCIENCE, 2001, 2 (05) :325-332
[3]   Chronic systemic pesticide exposure reproduces features of Parkinson's disease [J].
Betarbet, R ;
Sherer, TB ;
MacKenzie, G ;
Garcia-Osuna, M ;
Panov, AV ;
Greenamyre, JT .
NATURE NEUROSCIENCE, 2000, 3 (12) :1301-1306
[4]   Parkinson disease gene therapy moves toward the clinic [J].
Björklund, A ;
Lindvall, O .
NATURE MEDICINE, 2000, 6 (11) :1207-1208
[5]   Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model [J].
Björklund, LM ;
Sánchez-Pernaute, R ;
Chung, SM ;
Andersson, T ;
Chen, IYC ;
McNaught, KS ;
Brownell, AL ;
Jenkins, BG ;
Wahlestedt, C ;
Kim, KS ;
Isacson, O .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (04) :2344-2349
[6]   The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders [J].
Chung, KKK ;
Dawson, VL ;
Dawson, TM .
TRENDS IN NEUROSCIENCES, 2001, 24 (11) :S7-S14
[7]   Kinetic stabilization of the α-synuclein protofibril by a dopamine-α-synuclein adduct [J].
Conway, KA ;
Rochet, JC ;
Bieganski, RM ;
Lansbury, PT .
SCIENCE, 2001, 294 (5545) :1346-1349
[8]  
Date I, 2001, CELL TRANSPLANT, V10, P397
[9]   Animal models of PD: Pieces of the same puzzle? [J].
Dawson, TM ;
Mandir, AS ;
Lee, MK .
NEURON, 2002, 35 (02) :219-222
[10]   Prospects for new restorative and neuroprotective treatments in Parkinson's disease [J].
Dunnett, SB ;
Björklund, A .
NATURE, 1999, 399 (6738) :A32-A39
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